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Target
Isoform 2 of Nuclear receptor corepressor 2 (TRAC-1)
Ligand
BDBM66162
Substrate
n/a
Meas. Tech.
Counterscreen for agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3)
IC50
577.2±n/a nM
Citation
 PubChem, PC Counterscreen for agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3): TR-FRET-based biochemical high throughput dose response assay to identify agonists of the interaction between peroxisome proliferator-activated receptor gamma (PPARg) and nuclear receptor co-repressor 2 (NCOR2) PubChem Bioassay (2010)[AID] 
Target
Name:
Isoform 2 of Nuclear receptor corepressor 2 (TRAC-1)
Synonyms:
CTG26 | NCOR2 | NCOR2_HUMAN | Nuclear receptor corepressor 2 (TRAC-1) | nuclear receptor corepressor 2 isoform 2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
81401.89
Organism:
Homo sapiens (Human)
Description:
Q9Y618-2 gi_116256445
Residue:
766
Sequence:
MAQRADMLRGLSPRESSLALNYAAGPRGIIDLSQVPHLPVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERERDRDRERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSGGGGGSSSRPASHSHAHQHSPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAATFPPATHCPLGGTLDGVYPTLMEPVLLPKEAPRVARPERPRADTGHAFLAKPPARSGLEPASSPSKGSEPRPLVPPVSGHATIARTPAKNLAPHHASPDPPAPPASASDPHREKTQSKPFSIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLEGELRPKQPGPVKLGGEAAHLPHLRPLPESQPSSSPLLQTAPGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPLYSFPGASCPVLDLRRPPSDLYLPPPDHGAPARGSPHSEGGKRSPEPNKTSVLGGGEDGIEPVSPPEGMTEPGHSRSAVYPLLYRDGEQTEPSRMGSKSPGNTSQPPAFFSKLTESNSAMVKSKKQEINKKLNTHNRNEPEYNISQPGTEIFNMPAITGTGLMTYRSQAVQEHASTNMGLEAIIRKALMGGGGKAKVSGRPSSRKAKSPAPGLASGDRPPSVSSVHSEGDCNRRTPLTNRVWEDRPSSAGSTPFPYNPLIMRLQAGVMASPPPPGLPAGSGPLAGPHHAWDEEPKPLLCSQYETLSDSE
  
Inhibitor
Name:
BDBM66162
Synonyms:
5-(3a-hydroxy-2-keto-3,4,6,6a-tetrahydro-1H-thien[3,4-d]imidazol-4-yl)valeric acid methyl ester | 5-(3a-hydroxy-2-oxo-3,4,6,6a-tetrahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid methyl ester | MLS000533028 | SMR000140466 | cid_2849148 | methyl 5-(3a-hydroxy-2-oxo-3,4,6,6a-tetrahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoate | methyl 5-(3a-hydroxy-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoate | methyl 5-(3a-oxidanyl-2-oxidanylidene-3,4,6,6a-tetrahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoate
Type:
Small organic molecule
Emp. Form.:
C11H18N2O4S
Mol. Mass.:
274.337
SMILES:
COC(=O)CCCCC1SCC2NC(=O)NC12O
Structure:
Search PDB for entries with ligand similarity: