Reaction Details Report a problem with these data
Target
Signal transducer and activator of transcription 3 [702-738,740-752]
Ligand
BDBM43519
Substrate
n/a
Meas. Tech.
Late stage counterscreen results from the probe development effort to identify STAT1 inhibitors: luminescence-based cell-based dose response assay for STAT3 inhibitors
IC50
>55690±n/a nM
Citation
 PubChem, PC Late stage counterscreen results from the probe development effort to identify STAT1 inhibitors: luminescence-based cell-based dose response assay for STAT3 inhibitors PubChem Bioassay (2010)[AID] 
Target
Name:
Signal transducer and activator of transcription 3 [702-738,740-752]
Synonyms:
APRF | STAT3 | STAT3_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
5263.93
Organism:
Homo sapiens (Human)
Description:
gi_13272532
Residue:
50
Sequence:
AAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNGEGAEPSAGGQF
  
Inhibitor
Name:
BDBM43519
Synonyms:
3-[[4-(2-fluorophenyl)-1,3-thiazol-2-yl]methyl]-2-[(4-methylpiperazin-1-yl)methyl]quinazolin-4-one | 3-[[4-(2-fluorophenyl)-2-thiazolyl]methyl]-2-[(4-methyl-1-piperazinyl)methyl]-4-quinazolinone | 3-[[4-(2-fluorophenyl)thiazol-2-yl]methyl]-2-[(4-methylpiperazino)methyl]quinazolin-4-one | MLS000416421 | SMR000264258 | cid_4302443
Type:
Small organic molecule
Emp. Form.:
C24H24FN5OS
Mol. Mass.:
449.544
SMILES:
CN1CCN(Cc2nc3ccccc3c(=O)n2Cc2nc(cs2)-c2ccccc2F)CC1
Structure:
Search PDB for entries with ligand similarity: