Target
Signal transducer and activator of transcription 3 [702-738,740-752]
Ligand
BDBM67116
Substrate
n/a
Meas. Tech.
Late stage counterscreen results from the probe development effort to identify STAT1 inhibitors: luminescence-based cell-based dose response assay for STAT3 inhibitors
IC50
>55690±n/a nM
Citation
 PubChem, PC Late stage counterscreen results from the probe development effort to identify STAT1 inhibitors: luminescence-based cell-based dose response assay for STAT3 inhibitors PubChem Bioassay (2010)[AID] 
Target
Name:
Signal transducer and activator of transcription 3 [702-738,740-752]
Synonyms:
APRF | STAT3 | STAT3_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
5263.93
Organism:
Homo sapiens (Human)
Description:
gi_13272532
Residue:
50
Sequence:
AAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNGEGAEPSAGGQF
  
Inhibitor
Name:
BDBM67116
Synonyms:
2-[4-(2-cyanophenyl)sulfonyl-1-piperazinyl]-N-(2,5-dimethylphenyl)-2-phenylacetamide | 2-[4-(2-cyanophenyl)sulfonylpiperazin-1-yl]-N-(2,5-dimethylphenyl)-2-phenyl-ethanamide | 2-[4-(2-cyanophenyl)sulfonylpiperazin-1-yl]-N-(2,5-dimethylphenyl)-2-phenylacetamide | 2-[4-(2-cyanophenyl)sulfonylpiperazino]-N-(2,5-dimethylphenyl)-2-phenyl-acetamide | SR-03000000785-1 | cid_16362051
Type:
Small organic molecule
Emp. Form.:
C27H28N4O3S
Mol. Mass.:
488.601
SMILES:
Cc1ccc(C)c(NC(=O)C(N2CCN(CC2)S(=O)(=O)c2ccccc2C#N)c2ccccc2)c1
Structure:
Search PDB for entries with ligand similarity: