Reaction Details
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Signal transducer and activator of transcription 3 [702-738,740-752]
Ligand
BDBM67121
Substrate
n/a
Meas. Tech.
Late stage counterscreen results from the probe development effort to identify STAT1 inhibitors: luminescence-based cell-based dose response assay for STAT3 inhibitors
IC50
>55690±n/a nM
Citation
PubChem, PC Late stage counterscreen results from the probe development effort to identify STAT1 inhibitors: luminescence-based cell-based dose response assay for STAT3 inhibitors PubChem Bioassay (2010)[AID] More Info.:
Target
Name:
Signal transducer and activator of transcription 3 [702-738,740-752]
Synonyms:
APRF | STAT3 | STAT3_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
5263.93
Organism:
Homo sapiens (Human)
Description:
gi_13272532
Residue:
50
Sequence:
AAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNGEGAEPSAGGQF
Inhibitor
Name:
BDBM67121
Synonyms:
4-keto-N-methyl-3-phenyl-N-(2-pyrrolidinobenzyl)phthalazine-1-carboxamide | N-methyl-4-oxidanylidene-3-phenyl-N-[(2-pyrrolidin-1-ylphenyl)methyl]phthalazine-1-carboxamide | N-methyl-4-oxo-3-phenyl-N-[(2-pyrrolidin-1-ylphenyl)methyl]phthalazine-1-carboxamide | N-methyl-4-oxo-3-phenyl-N-[[2-(1-pyrrolidinyl)phenyl]methyl]-1-phthalazinecarboxamide | SR-03000000790-1 | cid_16329703
Type:
Small organic molecule
Emp. Form.:
C27H26N4O2
Mol. Mass.:
438.5209
SMILES:
CN(Cc1ccccc1N1CCCC1)C(=O)c1nn(-c2ccccc2)c(=O)c2ccccc12
Structure:
