Reaction Details
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Signal transducer and activator of transcription 3 [702-738,740-752]
Ligand
BDBM67133
Substrate
n/a
Meas. Tech.
Late stage counterscreen results from the probe development effort to identify STAT1 inhibitors: luminescence-based cell-based dose response assay for STAT3 inhibitors
IC50
>18560±n/a nM
Citation
PubChem, PC Late stage counterscreen results from the probe development effort to identify STAT1 inhibitors: luminescence-based cell-based dose response assay for STAT3 inhibitors PubChem Bioassay (2010)[AID] More Info.:
Target
Name:
Signal transducer and activator of transcription 3 [702-738,740-752]
Synonyms:
APRF | STAT3 | STAT3_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
5263.93
Organism:
Homo sapiens (Human)
Description:
gi_13272532
Residue:
50
Sequence:
AAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNGEGAEPSAGGQF
Inhibitor
Name:
BDBM67133
Synonyms:
(2E)-3-[[4-(3,4-difluorophenyl)-1,3-thiazol-2-yl]methyl]-2-(morpholin-4-ylmethylidene)-1H-quinazolin-4-one | (2E)-3-[[4-(3,4-difluorophenyl)-2-thiazolyl]methyl]-2-(4-morpholinylmethylidene)-1H-quinazolin-4-one | (2E)-3-[[4-(3,4-difluorophenyl)thiazol-2-yl]methyl]-2-(morpholinomethylene)-1H-quinazolin-4-one | (2E)-3-[[4-[3,4-bis(fluoranyl)phenyl]-1,3-thiazol-2-yl]methyl]-2-(morpholin-4-ylmethylidene)-1H-quinazolin-4-one | SR-03000000861-1 | cid_25181305
Type:
Small organic molecule
Emp. Form.:
C23H20F2N4O2S
Mol. Mass.:
454.492
SMILES:
Fc1ccc(cc1F)-c1csc(Cn2c(CN3CCOCC3)nc3ccccc3c2=O)n1
Structure:
