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Target
Signal transducer and activator of transcription 1-alpha/beta
Ligand
BDBM67109
Substrate
n/a
Meas. Tech.
Late stage results from the probe development effort to identify STAT1 inhibitors: luminescence-based cell-based dose response assay for STAT1 inhibitors
IC50
>55690±n/a nM
Citation
 PubChem, PC Late stage results from the probe development effort to identify STAT1 inhibitors: luminescence-based cell-based dose response assay for STAT1 inhibitors PubChem Bioassay (2010)[AID] 
Target
Name:
Signal transducer and activator of transcription 1-alpha/beta
Synonyms:
STAT1 | STAT1_HUMAN | Signal transducer and activator of transcription 1-alpha/beta | Transcription Factor STAT1 | Transcription factor ISGF-3 components p91/p84 | signal transducer and activator of transcription 1 isoform alpha
Type:
Cytosolic Transcription Factor
Mol. Mass.:
87327.69
Organism:
Homo sapiens (Human)
Description:
Stat1 was expressed in sf9 cells from a baculovirus encoding the recombinant proteins. Stat1 dimer binds to DNA.
Residue:
750
Sequence:
MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDLLSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQRFNQAQSGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQNREHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTELTQNALINDELVEWKRRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQVLWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLKVKVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQKNAGTRTNEGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLVAEPRNLSFFLTPPCARWAQLSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNASPDGLIPWTRFCKENINDKNFPFWLWIESILELIKKHLLPLWNDGCIMGFISKERERALLKDQQPGTFLLRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIPENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDGPKGTGYIKTELISVSEVHPSRLQTTDNLLPMSPEEFDEVSRIVGSVEFDSMMNTV
  
Inhibitor
Name:
BDBM67109
Synonyms:
2-(4-besylpiperazino)-N-[4-chloro-3-(trifluoromethyl)phenyl]-2-phenyl-acetamide | 2-[4-(benzenesulfonyl)-1-piperazinyl]-N-[4-chloro-3-(trifluoromethyl)phenyl]-2-phenylacetamide | 2-[4-(benzenesulfonyl)piperazin-1-yl]-N-[4-chloro-3-(trifluoromethyl)phenyl]-2-phenylacetamide | N-[4-chloranyl-3-(trifluoromethyl)phenyl]-2-phenyl-2-[4-(phenylsulfonyl)piperazin-1-yl]ethanamide | SR-03000000778-1 | cid_4852241
Type:
Small organic molecule
Emp. Form.:
C25H23ClF3N3O3S
Mol. Mass.:
537.982
SMILES:
FC(F)(F)c1cc(NC(=O)C(N2CCN(CC2)S(=O)(=O)c2ccccc2)c2ccccc2)ccc1Cl
Structure:
Search PDB for entries with ligand similarity: