Reaction Details Report a problem with these data
Target
Apelin receptor
Ligand
BDBM67166
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits from a small molecule antagonists of the APJ receptor via a luminescent beta-arrestin assay
IC50
3070±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits from a small molecule antagonists of the APJ receptor via a luminescent beta-arrestin assay PubChem Bioassay (2010)[AID] 
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
  
Inhibitor
Name:
BDBM67166
Synonyms:
(2R,3R)-2-(3-bromanyl-4-methoxy-phenyl)-6-methoxy-3-oxidanyl-2,3-dihydrochromen-4-one | (2R,3R)-2-(3-bromo-4-methoxy-phenyl)-3-hydroxy-6-methoxy-chroman-4-one | (2R,3R)-2-(3-bromo-4-methoxyphenyl)-3-hydroxy-6-methoxy-2,3-dihydrochromen-4-one | (2R,3R)-2-(3-bromo-4-methoxyphenyl)-3-hydroxy-6-methoxy-3,4-dihydro-2H-1-benzopyran-4-one | MLS000438767 | SMR000113160 | cid_6917582
Type:
Small organic molecule
Emp. Form.:
C17H15BrO5
Mol. Mass.:
379.202
SMILES:
COc1ccc2O[C@@H](C(=O)C(O)c2c1)c1ccc(OC)c(Br)c1
Structure:
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