Target
Apelin receptor
Ligand
BDBM67169
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits from a small molecule antagonists of the APJ receptor via a luminescent beta-arrestin assay
IC50
32600±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits from a small molecule antagonists of the APJ receptor via a luminescent beta-arrestin assay PubChem Bioassay (2010)[AID] 
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
  
Inhibitor
Name:
BDBM67169
Synonyms:
4-methoxy-2-[2-(8-methoxy-2-quinolinyl)vinyl]-6-nitrophenyl acetate | MLS000536984 | SMR000143621 | [4-methoxy-2-[(E)-2-(8-methoxyquinolin-2-yl)ethenyl]-6-nitro-phenyl] ethanoate | [4-methoxy-2-[(E)-2-(8-methoxyquinolin-2-yl)ethenyl]-6-nitrophenyl] acetate | acetic acid [4-methoxy-2-[(E)-2-(8-methoxy-2-quinolinyl)ethenyl]-6-nitrophenyl] ester | acetic acid [4-methoxy-2-[(E)-2-(8-methoxy-2-quinolyl)vinyl]-6-nitro-phenyl] ester | cid_5740287
Type:
Small organic molecule
Emp. Form.:
C21H18N2O6
Mol. Mass.:
394.3774
SMILES:
COc1cc(\C=C\c2ccc3cccc(OC)c3n2)c(OC(C)=O)c(c1)[N+]([O-])=O
Structure:
Search PDB for entries with ligand similarity: