Reaction Details Report a problem with these data
Target
Apelin receptor
Ligand
BDBM67230
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits from a small molecule antagonists of the APJ receptor via a luminescent beta-arrestin assay
IC50
3480±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits from a small molecule antagonists of the APJ receptor via a luminescent beta-arrestin assay PubChem Bioassay (2010)[AID] 
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
  
Inhibitor
Name:
BDBM67230
Synonyms:
MLS000585349 | N-[2-(4-chlorophenyl)-2-oxoethyl]-3-phenyl-N,N-dipropylprop-2-yn-1-aminium | SMR000204112 | [2-(4-chlorophenyl)-2-keto-ethyl]-(3-phenylprop-2-ynyl)-dipropyl-ammonium | [2-(4-chlorophenyl)-2-oxidanylidene-ethyl]-(3-phenylprop-2-ynyl)-dipropyl-azanium | [2-(4-chlorophenyl)-2-oxoethyl]-(3-phenylprop-2-ynyl)-dipropylammonium | [2-(4-chlorophenyl)-2-oxoethyl]-(3-phenylprop-2-ynyl)-dipropylazanium | cid_12005158
Type:
Small organic molecule
Emp. Form.:
C23H27ClNO
Mol. Mass.:
368.919
SMILES:
CCC[N+](CCC)(CC#Cc1ccccc1)CC(=O)c1ccc(Cl)cc1
Structure:
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