Reaction Details Report a problem with these data
Target
Tumor necrosis factor
Ligand
BDBM62388
Substrate
n/a
Meas. Tech.
SAR analysis of inhibitors of TNFa specific NF-kB induction - Set 3
IC50
>20000±n/a nM
Citation
 PubChem, PC SAR analysis of inhibitors of TNFa specific NF-kB induction - Set 3 PubChem Bioassay (2010)[AID] 
Target
Name:
Tumor necrosis factor
Synonyms:
Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha
Type:
Enzyme
Mol. Mass.:
25645.11
Organism:
Homo sapiens (Human)
Description:
P01375
Residue:
233
Sequence:
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
  
Inhibitor
Name:
BDBM62388
Synonyms:
MLS-0412035.0001 | N-(3-amino-4-chloro-phenyl)-1-hydroxy-2-naphthamide | N-(3-amino-4-chlorophenyl)-1-hydroxy-2-naphthalenecarboxamide | N-(3-amino-4-chlorophenyl)-1-hydroxynaphthalene-2-carboxamide | N-(3-azanyl-4-chloranyl-phenyl)-1-oxidanyl-naphthalene-2-carboxamide | cid_830761
Type:
Small organic molecule
Emp. Form.:
C17H13ClN2O2
Mol. Mass.:
312.75
SMILES:
Nc1cc(NC(=O)c2ccc3ccccc3c2O)ccc1Cl
Structure:
Search PDB for entries with ligand similarity: