Reaction Details Report a problem with these data
Target
Female germline-specific tumor suppressor gld-1
Ligand
BDBM67435
Substrate
n/a
Meas. Tech.
Fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of GLD-1 protein - TGE RNA interaction
IC50
2427±n/a nM
Citation
 PubChem, PC Fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of GLD-1 protein - TGE RNA interaction PubChem Bioassay (2010)[AID] 
Target
Name:
Female germline-specific tumor suppressor gld-1
Synonyms:
GLD1_CAEEL | defective in Germ Line Development family member (gld-1) | gld-1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50591.33
Organism:
Caenorhabditis elegans
Description:
gi_17507875
Residue:
463
Sequence:
MPSCTTPTYGVSTQLESQSSESPSRSSVMTPTSLDGDNSPRKRFPIIDNVPADRWPSTRRDGWSSVRAPPPARLTLSTNNRHIMSPISSAYSQTPNSLLSPAMFNPKSRSIFSPTLPATPMSYGKSSMDKSLFSPTATEPIEVEATVEYLADLVKEKKHLTLFPHMFSNVERLLDDEIGRVRVALFQTEFPRVELPEPAGDMISITEKIYVPKNEYPDYNFVGRILGPRGMTAKQLEQDTGCKIMVRGKGSMRDKSKESAHRGKANWEHLEDDLHVLVQCEDTENRVHIKLQAALEQVKKLLIPAPEGTDELKRKQLMELAIINGTYRPMKSPNPARVMTAVPLLSPTPLRSSGPVLMSPTPGSGLPSTTFGGSILSPTLTASNLLGSNVFDYSLLSPSMFDSFSSLQLASDLTFPKYPTTTSFVNSFPGLFTSASSFANQTNTNVSPSGASPSASSVNNTSF
  
Inhibitor
Name:
BDBM67435
Synonyms:
(E)-3-(1,3-benzothiazol-2-yl)-4-(3-hydroxy-4-methoxy-phenyl)but-3-enoic acid | (E)-3-(1,3-benzothiazol-2-yl)-4-(3-hydroxy-4-methoxyphenyl)-3-butenoic acid | (E)-3-(1,3-benzothiazol-2-yl)-4-(3-hydroxy-4-methoxyphenyl)but-3-enoic acid | (E)-3-(1,3-benzothiazol-2-yl)-4-(4-methoxy-3-oxidanyl-phenyl)but-3-enoic acid | MLS000775760 | SMR000369319 | cid_6292079
Type:
Small organic molecule
Emp. Form.:
C18H15NO4S
Mol. Mass.:
341.381
SMILES:
COc1ccc(\C=C(/CC(O)=O)c2nc3ccccc3s2)cc1O
Structure:
Search PDB for entries with ligand similarity: