Reaction Details Report a problem with these data
Target
Female germline-specific tumor suppressor gld-1
Ligand
BDBM52859
Substrate
n/a
Meas. Tech.
Fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of GLD-1 protein - TGE RNA interaction
IC50
9411±n/a nM
Citation
 PubChem, PC Fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of GLD-1 protein - TGE RNA interaction PubChem Bioassay (2010)[AID] 
Target
Name:
Female germline-specific tumor suppressor gld-1
Synonyms:
GLD1_CAEEL | defective in Germ Line Development family member (gld-1) | gld-1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50591.33
Organism:
Caenorhabditis elegans
Description:
gi_17507875
Residue:
463
Sequence:
MPSCTTPTYGVSTQLESQSSESPSRSSVMTPTSLDGDNSPRKRFPIIDNVPADRWPSTRRDGWSSVRAPPPARLTLSTNNRHIMSPISSAYSQTPNSLLSPAMFNPKSRSIFSPTLPATPMSYGKSSMDKSLFSPTATEPIEVEATVEYLADLVKEKKHLTLFPHMFSNVERLLDDEIGRVRVALFQTEFPRVELPEPAGDMISITEKIYVPKNEYPDYNFVGRILGPRGMTAKQLEQDTGCKIMVRGKGSMRDKSKESAHRGKANWEHLEDDLHVLVQCEDTENRVHIKLQAALEQVKKLLIPAPEGTDELKRKQLMELAIINGTYRPMKSPNPARVMTAVPLLSPTPLRSSGPVLMSPTPGSGLPSTTFGGSILSPTLTASNLLGSNVFDYSLLSPSMFDSFSSLQLASDLTFPKYPTTTSFVNSFPGLFTSASSFANQTNTNVSPSGASPSASSVNNTSF
  
Inhibitor
Name:
BDBM52859
Synonyms:
(4Z)-2-ethyl-4-(2-thenylidene)-1,3-dihydrobenzo[b][1,6]naphthyridine-10-carboxylic acid | (4Z)-2-ethyl-4-(thiophen-2-ylmethylidene)-1,3-dihydrobenzo[b][1,6]naphthyridine-10-carboxylic acid | MLS001003079 | SMR000372730 | cid_7515944
Type:
Small organic molecule
Emp. Form.:
C20H18N2O2S
Mol. Mass.:
350.434
SMILES:
CCN1C\C(=C\c2cccs2)c2nc3ccccc3c(C(O)=O)c2C1
Structure:
Search PDB for entries with ligand similarity: