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Target
Female germline-specific tumor suppressor gld-1
Ligand
BDBM67449
Substrate
n/a
Meas. Tech.
Fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of GLD-1 protein - TGE RNA interaction
IC50
4074±n/a nM
Citation
 PubChem, PC Fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of GLD-1 protein - TGE RNA interaction PubChem Bioassay (2010)[AID] 
Target
Name:
Female germline-specific tumor suppressor gld-1
Synonyms:
GLD1_CAEEL | defective in Germ Line Development family member (gld-1) | gld-1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50591.33
Organism:
Caenorhabditis elegans
Description:
gi_17507875
Residue:
463
Sequence:
MPSCTTPTYGVSTQLESQSSESPSRSSVMTPTSLDGDNSPRKRFPIIDNVPADRWPSTRRDGWSSVRAPPPARLTLSTNNRHIMSPISSAYSQTPNSLLSPAMFNPKSRSIFSPTLPATPMSYGKSSMDKSLFSPTATEPIEVEATVEYLADLVKEKKHLTLFPHMFSNVERLLDDEIGRVRVALFQTEFPRVELPEPAGDMISITEKIYVPKNEYPDYNFVGRILGPRGMTAKQLEQDTGCKIMVRGKGSMRDKSKESAHRGKANWEHLEDDLHVLVQCEDTENRVHIKLQAALEQVKKLLIPAPEGTDELKRKQLMELAIINGTYRPMKSPNPARVMTAVPLLSPTPLRSSGPVLMSPTPGSGLPSTTFGGSILSPTLTASNLLGSNVFDYSLLSPSMFDSFSSLQLASDLTFPKYPTTTSFVNSFPGLFTSASSFANQTNTNVSPSGASPSASSVNNTSF
  
Inhibitor
Name:
BDBM67449
Synonyms:
2-(2,4-diketo-1,3-diazaspiro[4.5]decan-3-yl)acetic acid [2-keto-4-(trifluoromethyl)chromen-7-yl] ester | 2-(2,4-dioxo-1,3-diazaspiro[4.5]decan-3-yl)acetic acid [2-oxo-4-(trifluoromethyl)-1-benzopyran-7-yl] ester | MLS001141678 | SMR000705589 | [2-oxidanylidene-4-(trifluoromethyl)chromen-7-yl] 2-[2,4-bis(oxidanylidene)-1,3-diazaspiro[4.5]decan-3-yl]ethanoate | [2-oxo-4-(trifluoromethyl)chromen-7-yl] 2-(2,4-dioxo-1,3-diazaspiro[4.5]decan-3-yl)acetate | cid_16281348
Type:
Small organic molecule
Emp. Form.:
C20H17F3N2O6
Mol. Mass.:
438.354
SMILES:
FC(F)(F)c1cc(=O)oc2cc(OC(=O)CN3C(=O)NC4(CCCCC4)C3=O)ccc12
Structure:
Search PDB for entries with ligand similarity: