Reaction Details Report a problem with these data
Target
NADPH oxidase 1
Ligand
BDBM67521
Substrate
n/a
Meas. Tech.
Late-stage luminescence-based cell-based dose response assay to identify inhibitors of NADPH oxidase 1 (NOX1): Purchased analogs
IC50
4448±n/a nM
Citation
 PubChem, PC Late-stage luminescence-based cell-based dose response assay to identify inhibitors of NADPH oxidase 1 (NOX1): Purchased analogs PubChem Bioassay (2010)[AID] 
Target
Name:
NADPH oxidase 1
Synonyms:
MOX-1 | MOX1 | Mitogenic oxidase 1 | NADH/NADPH mitogenic oxidase subunit P65-MOX | NOH-1 | NOH1 | NOX-1 | NOX1 | NOX1_HUMAN
Type:
PROTEIN
Mol. Mass.:
64890.44
Organism:
Homo sapiens (Human)
Description:
ChEMBL_792877
Residue:
564
Sequence:
MGNWVVNHWFSVLFLVVWLGLNVFLFVDAFLKYEKADKYYYTRKILGSTLACARASALCLNFNSTLILLPVCRNLLSFLRGTCSFCSRTLRKQLDHNLTFHKLVAYMICLHTAIHIIAHLFNFDCYSRSRQATDGSLASILSSLSHDEKKGGSWLNPIQSRNTTVEYVTFTSIAGLTGVIMTIALILMVTSATEFIRRSYFEVFWYTHHLFIFYILGLGIHGIGGIVRGQTEESMNESHPRKCAESFEMWDDRDSHCRRPKFEGHPPESWKWILAPVILYICERILRFYRSQQKVVITKVVMHPSKVLELQMNKRGFSMEVGQYIFVNCPSISLLEWHPFTLTSAPEEDFFSIHIRAAGDWTENLIRAFEQQYSPIPRIEVDGPFGTASEDVFQYEVAVLVGAGIGVTPFASILKSIWYKFQCADHNLKTKKIYFYWICRETGAFSWFNNLLTSLEQEMEELGKVGFLNYRLFLTGWDSNIVGHAALNFDKATDIVTGLKQKTSFGRPMWDNEFSTIATSHPKSVVGVFLCGPRTLAKSLRKCCHRYSSLDPRKVQFYFNKENF
  
Inhibitor
Name:
BDBM67521
Synonyms:
3,5,6-trichloro-4-[1-(4-hydroxyphenyl)ethenylhydrazo]-2-pyridinecarboxylic acid | 3,5,6-trichloro-4-[2-[1-(4-hydroxyphenyl)ethenyl]hydrazinyl]pyridine-2-carboxylic acid | 3,5,6-trichloro-4-[N'-[1-(4-hydroxyphenyl)vinyl]hydrazino]picolinic acid | 3,5,6-tris(chloranyl)-4-[2-[1-(4-hydroxyphenyl)ethenyl]hydrazinyl]pyridine-2-carboxylic acid | SR-03000000743-1 | cid_25181289
Type:
Small organic molecule
Emp. Form.:
C14H10Cl3N3O3
Mol. Mass.:
374.607
SMILES:
CC(N=Nc1c(Cl)c(Cl)nc(C(O)=O)c1Cl)c1ccc(O)cc1 |w:3.3|
Structure:
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