Target
Guanine nucleotide-binding protein G(o) subunit alpha
Ligand
BDBM67699
Substrate
n/a
Meas. Tech.
Dose response, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS7-Galphao with additional round of SAR compounds.
EC50
>30000±0 nM
Citation
 PubChem, PC Dose response, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS7-Galphao with additional round of SAR compounds. PubChem Bioassay (2010)[AID] 
Target
Name:
Guanine nucleotide-binding protein G(o) subunit alpha
Synonyms:
GNAO1 | GNAO_HUMAN | Guanine nucleotide-binding protein G(o), alpha subunit 1 | guanine nucleotide-binding protein G(o) subunit alpha isoform a
Type:
PROTEIN
Mol. Mass.:
40043.59
Organism:
Homo sapiens (Human)
Description:
ChEMBL_321106
Residue:
354
Sequence:
MGCTLSAEERAALERSKAIEKNLKEDGISAAKDVKLLLLGAGESGKSTIVKQMKIIHEDGFSGEDVKQYKPVVYSNTIQSLAAIVRAMDTLGIEYGDKERKADAKMVCDVVSRMEDTEPFSAELLSAMMRLWGDSGIQECFNRSREYQLNDSAKYYLDSLDRIGAADYQPTEQDILRTRVKTTGIVETHFTFKNLHFRLFDVGGQRSERKKWIHCFEDVTAIIFCVALSGYDQVLHEDETTNRMHESLMLFDSICNNKFFIDTSIILFLNKKDLFGEKIKKSPLTICFPEYTGPNTYEDAAAYIQAQFESKNRSPNKEIYCHMTCATDTNNIQVVFDAVTDIIIANNLRGCGLY
  
Inhibitor
Name:
BDBM67699
Synonyms:
(3-chloranyl-6-nitro-1-benzothiophen-2-yl)-piperazin-1-yl-methanone | (3-chloro-6-nitro-1-benzothiophen-2-yl)-(1-piperazinyl)methanone | (3-chloro-6-nitro-1-benzothiophen-2-yl)-piperazin-1-ylmethanone | (3-chloro-6-nitro-benzothiophen-2-yl)-piperazino-methanone | KSC-1-99c | KUC103872N | cid_4496360
Type:
Small organic molecule
Emp. Form.:
C13H12ClN3O3S
Mol. Mass.:
325.771
SMILES:
[O-][N+](=O)c1ccc2c(Cl)c(sc2c1)C(=O)N1CCNCC1
Structure:
Search PDB for entries with ligand similarity: