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Target
Guanine nucleotide-binding protein G(o) subunit alpha
Ligand
BDBM67701
Substrate
n/a
Meas. Tech.
Dose response, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS8-Galphao with additional round of SAR compounds
EC50
>30000±0 nM
Citation
 PubChem, PC Dose response, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS8-Galphao with additional round of SAR compounds PubChem Bioassay (2010)[AID] 
Target
Name:
Guanine nucleotide-binding protein G(o) subunit alpha
Synonyms:
GNAO1 | GNAO_HUMAN | Guanine nucleotide-binding protein G(o), alpha subunit 1 | guanine nucleotide-binding protein G(o) subunit alpha isoform a
Type:
PROTEIN
Mol. Mass.:
40043.59
Organism:
Homo sapiens (Human)
Description:
ChEMBL_321106
Residue:
354
Sequence:
MGCTLSAEERAALERSKAIEKNLKEDGISAAKDVKLLLLGAGESGKSTIVKQMKIIHEDGFSGEDVKQYKPVVYSNTIQSLAAIVRAMDTLGIEYGDKERKADAKMVCDVVSRMEDTEPFSAELLSAMMRLWGDSGIQECFNRSREYQLNDSAKYYLDSLDRIGAADYQPTEQDILRTRVKTTGIVETHFTFKNLHFRLFDVGGQRSERKKWIHCFEDVTAIIFCVALSGYDQVLHEDETTNRMHESLMLFDSICNNKFFIDTSIILFLNKKDLFGEKIKKSPLTICFPEYTGPNTYEDAAAYIQAQFESKNRSPNKEIYCHMTCATDTNNIQVVFDAVTDIIIANNLRGCGLY
  
Inhibitor
Name:
BDBM67701
Synonyms:
3-chloranyl-6-methyl-N-(3-morpholin-4-ylpropyl)-1-benzothiophene-2-carboxamide | 3-chloro-6-methyl-N-(3-morpholin-4-ylpropyl)-1-benzothiophene-2-carboxamide | 3-chloro-6-methyl-N-(3-morpholinopropyl)benzothiophene-2-carboxamide | 3-chloro-6-methyl-N-[3-(4-morpholinyl)propyl]-1-benzothiophene-2-carboxamide | KSC-1-101c | KUC103874N | cid_3579902
Type:
Small organic molecule
Emp. Form.:
C17H21ClN2O2S
Mol. Mass.:
352.879
SMILES:
Cc1ccc2c(Cl)c(sc2c1)C(=O)NCCCN1CCOCC1
Structure:
Search PDB for entries with ligand similarity: