Target
Guanine nucleotide-binding protein G(o) subunit alpha
Ligand
BDBM67702
Substrate
n/a
Meas. Tech.
Dose response, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS4-Galphao with additional round of SAR compounds.
EC50
>30000±0 nM
Citation
 PubChem, PC Dose response, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS4-Galphao with additional round of SAR compounds. PubChem Bioassay (2010)[AID] 
Target
Name:
Guanine nucleotide-binding protein G(o) subunit alpha
Synonyms:
GNAO1 | GNAO_HUMAN | Guanine nucleotide-binding protein G(o), alpha subunit 1 | guanine nucleotide-binding protein G(o) subunit alpha isoform a
Type:
PROTEIN
Mol. Mass.:
40043.59
Organism:
Homo sapiens (Human)
Description:
ChEMBL_321106
Residue:
354
Sequence:
MGCTLSAEERAALERSKAIEKNLKEDGISAAKDVKLLLLGAGESGKSTIVKQMKIIHEDGFSGEDVKQYKPVVYSNTIQSLAAIVRAMDTLGIEYGDKERKADAKMVCDVVSRMEDTEPFSAELLSAMMRLWGDSGIQECFNRSREYQLNDSAKYYLDSLDRIGAADYQPTEQDILRTRVKTTGIVETHFTFKNLHFRLFDVGGQRSERKKWIHCFEDVTAIIFCVALSGYDQVLHEDETTNRMHESLMLFDSICNNKFFIDTSIILFLNKKDLFGEKIKKSPLTICFPEYTGPNTYEDAAAYIQAQFESKNRSPNKEIYCHMTCATDTNNIQVVFDAVTDIIIANNLRGCGLY
  
Inhibitor
Name:
BDBM67702
Synonyms:
3-chloranyl-N-(3-imidazol-1-ylpropyl)-6-nitro-1-benzothiophene-2-carboxamide | 3-chloro-N-(3-imidazol-1-ylpropyl)-6-nitro-1-benzothiophene-2-carboxamide | 3-chloro-N-(3-imidazol-1-ylpropyl)-6-nitro-benzothiophene-2-carboxamide | 3-chloro-N-[3-(1-imidazolyl)propyl]-6-nitro-1-benzothiophene-2-carboxamide | KSC-1-102c | KUC103875N | cid_2933863
Type:
Small organic molecule
Emp. Form.:
C15H13ClN4O3S
Mol. Mass.:
364.807
SMILES:
[O-][N+](=O)c1ccc2c(Cl)c(sc2c1)C(=O)NCCCn1ccnc1
Structure:
Search PDB for entries with ligand similarity: