Reaction Details Report a problem with these data
Target
DNA damage-inducible transcript 3 protein
Ligand
BDBM67822
Substrate
n/a
Meas. Tech.
Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress
IC50
610±n/a nM
Citation
 PubChem, PC Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress PubChem Bioassay (2010)[AID] 
Target
Name:
DNA damage-inducible transcript 3 protein
Synonyms:
Chop | Chop10 | DDIT3_MOUSE | Ddit3 | Gadd153
Type:
Enzyme Catalytic Domain
Mol. Mass.:
19175.17
Organism:
Mus musculus
Description:
gi_160707929
Residue:
168
Sequence:
MAAESLPFTLETVSSWELEAWYEDLQEVLSSDEIGGTYISSPGNEEEESKTFTTLDPASLAWLTEEPGPTEVTRTSQSPRSPDSSQSSMAQEEEEEEQGRTRKRKQSGQCPARPGKQRMKEKEQENERKVAQLAEENERLKQEIERLTREVETTRRALIDRMVSLHQA
  
Inhibitor
Name:
BDBM67822
Synonyms:
1-[2-(2,4-dichlorophenoxy)ethyl]-3-methyl-1,3-dihydro-2H-benzimidazol-2-one | 1-[2-(2,4-dichlorophenoxy)ethyl]-3-methyl-2-benzimidazolone | 1-[2-(2,4-dichlorophenoxy)ethyl]-3-methyl-benzimidazol-2-one | 1-[2-(2,4-dichlorophenoxy)ethyl]-3-methylbenzimidazol-2-one | 1-[2-[2,4-bis(chloranyl)phenoxy]ethyl]-3-methyl-benzimidazol-2-one | MLS000535113 | SMR000142546 | cid_748782
Type:
Small organic molecule
Emp. Form.:
C16H14Cl2N2O2
Mol. Mass.:
337.201
SMILES:
Cn1c2ccccc2n(CCOc2ccc(Cl)cc2Cl)c1=O
Structure:
Search PDB for entries with ligand similarity: