Reaction Details Report a problem with these data
Target
DNA damage-inducible transcript 3 protein
Ligand
BDBM67903
Substrate
n/a
Meas. Tech.
Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress
IC50
300±n/a nM
Citation
 PubChem, PC Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress PubChem Bioassay (2010)[AID] 
Target
Name:
DNA damage-inducible transcript 3 protein
Synonyms:
Chop | Chop10 | DDIT3_MOUSE | Ddit3 | Gadd153
Type:
Enzyme Catalytic Domain
Mol. Mass.:
19175.17
Organism:
Mus musculus
Description:
gi_160707929
Residue:
168
Sequence:
MAAESLPFTLETVSSWELEAWYEDLQEVLSSDEIGGTYISSPGNEEEESKTFTTLDPASLAWLTEEPGPTEVTRTSQSPRSPDSSQSSMAQEEEEEEQGRTRKRKQSGQCPARPGKQRMKEKEQENERKVAQLAEENERLKQEIERLTREVETTRRALIDRMVSLHQA
  
Inhibitor
Name:
BDBM67903
Synonyms:
(4-chlorophenyl)(4-{[(2,4-dichlorophenyl)sulfanyl]methyl}-4-hydroxypiperidino)methanone | (4-chlorophenyl)-[4-[(2,4-dichlorophenyl)sulfanylmethyl]-4-hydroxypiperidin-1-yl]methanone | (4-chlorophenyl)-[4-[(2,4-dichlorophenyl)sulfanylmethyl]-4-oxidanyl-piperidin-1-yl]methanone | (4-chlorophenyl)-[4-[[(2,4-dichlorophenyl)thio]methyl]-4-hydroxy-1-piperidinyl]methanone | (4-chlorophenyl)-[4-[[(2,4-dichlorophenyl)thio]methyl]-4-hydroxy-piperidino]methanone | MLS000326998 | SMR000179615 | cid_1489029
Type:
Small organic molecule
Emp. Form.:
C19H18Cl3NO2S
Mol. Mass.:
430.776
SMILES:
OC1(CSc2ccc(Cl)cc2Cl)CCN(CC1)C(=O)c1ccc(Cl)cc1
Structure:
Search PDB for entries with ligand similarity: