Reaction Details Report a problem with these data
Target
DNA damage-inducible transcript 3 protein
Ligand
BDBM33125
Substrate
n/a
Meas. Tech.
Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress
IC50
590±n/a nM
Citation
 PubChem, PC Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress PubChem Bioassay (2010)[AID] 
Target
Name:
DNA damage-inducible transcript 3 protein
Synonyms:
Chop | Chop10 | DDIT3_MOUSE | Ddit3 | Gadd153
Type:
Enzyme Catalytic Domain
Mol. Mass.:
19175.17
Organism:
Mus musculus
Description:
gi_160707929
Residue:
168
Sequence:
MAAESLPFTLETVSSWELEAWYEDLQEVLSSDEIGGTYISSPGNEEEESKTFTTLDPASLAWLTEEPGPTEVTRTSQSPRSPDSSQSSMAQEEEEEEQGRTRKRKQSGQCPARPGKQRMKEKEQENERKVAQLAEENERLKQEIERLTREVETTRRALIDRMVSLHQA
  
Inhibitor
Name:
BDBM33125
Synonyms:
2-[1-[(Z)-1-(4-methoxyphenyl)-3-oxidanylidene-3-thiophen-2-yl-prop-1-en-2-yl]pyridin-2-ylidene]propanedinitrile | 2-[1-[(Z)-1-(4-methoxyphenyl)-3-oxo-3-thiophen-2-ylprop-1-en-2-yl]-2-pyridinylidene]propanedinitrile | 2-[1-[(Z)-1-(4-methoxyphenyl)-3-oxo-3-thiophen-2-ylprop-1-en-2-yl]pyridin-2-ylidene]propanedinitrile | 2-[1-[(Z)-2-(4-methoxyphenyl)-1-(2-thenoyl)vinyl]-2-pyridylidene]malononitrile | MLS000418543 | SMR000265055 | cid_6019083
Type:
Small organic molecule
Emp. Form.:
C22H15N3O2S
Mol. Mass.:
385.438
SMILES:
COc1ccc(\C=C(/N2C=CC=CC2=C(C#N)C#N)C(=O)c2cccs2)cc1 |c:9,11|
Structure:
Search PDB for entries with ligand similarity: