Reaction Details Report a problem with these data
Target
DNA damage-inducible transcript 3 protein
Ligand
BDBM57635
Substrate
n/a
Meas. Tech.
Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress
IC50
580±n/a nM
Citation
 PubChem, PC Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress PubChem Bioassay (2010)[AID] 
Target
Name:
DNA damage-inducible transcript 3 protein
Synonyms:
Chop | Chop10 | DDIT3_MOUSE | Ddit3 | Gadd153
Type:
Enzyme Catalytic Domain
Mol. Mass.:
19175.17
Organism:
Mus musculus
Description:
gi_160707929
Residue:
168
Sequence:
MAAESLPFTLETVSSWELEAWYEDLQEVLSSDEIGGTYISSPGNEEEESKTFTTLDPASLAWLTEEPGPTEVTRTSQSPRSPDSSQSSMAQEEEEEEQGRTRKRKQSGQCPARPGKQRMKEKEQENERKVAQLAEENERLKQEIERLTREVETTRRALIDRMVSLHQA
  
Inhibitor
Name:
BDBM57635
Synonyms:
MLS000722278 | N-[2-(1H-benzimidazol-2-yl)phenyl]-3-chloranyl-1-benzothiophene-2-carboxamide | N-[2-(1H-benzimidazol-2-yl)phenyl]-3-chloro-1-benzothiophene-2-carboxamide | N-[2-(1H-benzimidazol-2-yl)phenyl]-3-chloro-benzothiophene-2-carboxamide | SMR000235965 | cid_4246134
Type:
Small organic molecule
Emp. Form.:
C22H14ClN3OS
Mol. Mass.:
403.884
SMILES:
Clc1c(sc2ccccc12)C(=O)Nc1ccccc1-c1nc2ccccc2[nH]1
Structure:
Search PDB for entries with ligand similarity: