Reaction Details Report a problem with these data
Target
DNA damage-inducible transcript 3 protein
Ligand
BDBM68185
Substrate
n/a
Meas. Tech.
Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress
IC50
360±n/a nM
Citation
 PubChem, PC Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress PubChem Bioassay (2010)[AID] 
Target
Name:
DNA damage-inducible transcript 3 protein
Synonyms:
Chop | Chop10 | DDIT3_MOUSE | Ddit3 | Gadd153
Type:
Enzyme Catalytic Domain
Mol. Mass.:
19175.17
Organism:
Mus musculus
Description:
gi_160707929
Residue:
168
Sequence:
MAAESLPFTLETVSSWELEAWYEDLQEVLSSDEIGGTYISSPGNEEEESKTFTTLDPASLAWLTEEPGPTEVTRTSQSPRSPDSSQSSMAQEEEEEEQGRTRKRKQSGQCPARPGKQRMKEKEQENERKVAQLAEENERLKQEIERLTREVETTRRALIDRMVSLHQA
  
Inhibitor
Name:
BDBM68185
Synonyms:
1-(tert-butyl)-4-[({[(4-chloroanilino)carbonyl]oxy}imino)methyl]-3,5-dimethyl-1H-pyrazole | MLS000851305 | N-(4-chlorophenyl)carbamic acid [(1-tert-butyl-3,5-dimethyl-4-pyrazolyl)methylideneamino] ester | N-(4-chlorophenyl)carbamic acid [(1-tert-butyl-3,5-dimethyl-pyrazol-4-yl)methyleneamino] ester | SMR000457648 | [(1-tert-butyl-3,5-dimethyl-pyrazol-4-yl)methylideneamino] N-(4-chlorophenyl)carbamate | [(1-tert-butyl-3,5-dimethylpyrazol-4-yl)methylideneamino] N-(4-chlorophenyl)carbamate | cid_2804813
Type:
Small organic molecule
Emp. Form.:
C17H21ClN4O2
Mol. Mass.:
348.827
SMILES:
Cc1nn(c(C)c1C=NOC(=O)Nc1ccc(Cl)cc1)C(C)(C)C |w:8.9|
Structure:
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