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Target
ATP-dependent molecular chaperone HSP82
Ligand
BDBM40563
Substrate
n/a
Meas. Tech.
Fluorescence Cell-Based Secondary Assay of Resistant C. albicans Growth in the Presence of Fluconazole
EC50
2355±n/a nM
Citation
 PubChem, PC Fluorescence Cell-Based Secondary Assay of Resistant C. albicans Growth in the Presence of Fluconazole PubChem Bioassay (2010)[AID] 
Target
Name:
ATP-dependent molecular chaperone HSP82
Synonyms:
heat shock protein 90
Type:
Enzyme Catalytic Domain
Mol. Mass.:
80784.12
Organism:
Candida albicans
Description:
gi_994798
Residue:
707
Sequence:
MADAKVETHEFTAEISQLMSLIINTVYSNKEIFLRELISNASDALDKIRYQALSDPSQLESEPELFIRIIPQKDQKVLEIRDSGIGMTKADLVNNLGTIAKSGTKSFMEALSAGADVSMIGQFGVGFYSLFLVADHVQVISKHNDDEQYVWESNAGGKFTVTLDETNERLGRGTMLRLFLKEDQLEYLEEKRIKEVVKKHSEFVAYPIQLVVTKEVEKEVPETEEEDKAAEEDDKKPKLEEVKDEEDEKKEKKTKTVKEEVTETEELNKTKPLWTRNPSDITQDEYNAFYKSISNDWEDPLAVKHFSVEGQLEFRAILFVPKRAPFDAFESKKKKNNIKLYVRRVFITDDAEELIPEWLSFIKGVVDSEDLPLNLSREMLQQNKILKVIRKNIVKKMIETFNEISEDQEQFNQFYTAFSKNIKLGIHEDAQNRQSLAKLLRFYSTKSSEEMTSLSDYVTRMPEHQKNIYYITGESIKAVEKSPFLDALKAKNFEVLFMVDPIDEYAMTQLKEFEDKKLVDITKDFELEESDEEKAAREKEIKEYEPLTKALKDILGDQVEKVVVSYKLVDAPAAIRTGQFGWSANMERIMKAQALRDTTMSSYMSSKKTFEISPSSPIIKELKKKVETDGAEDKTVKDLTTLLFDTALLTSGFTLDEPSNFAHRINRLIALGLNIDDDSEETAVEPEATTTASTDEPAGESAMEEVD
  
Inhibitor
Name:
BDBM40563
Synonyms:
5-bromanyl-N-(4-pyridin-2-yl-1,3-thiazol-2-yl)thiophene-2-carboxamide | 5-bromo-N-(4-pyridin-2-yl-1,3-thiazol-2-yl)thiophene-2-carboxamide | 5-bromo-N-[4-(2-pyridinyl)-2-thiazolyl]-2-thiophenecarboxamide | 5-bromo-N-[4-(2-pyridyl)thiazol-2-yl]thiophene-2-carboxamide | MLS000564382 | SMR000151923 | cid_2354167
Type:
Small organic molecule
Emp. Form.:
C13H8BrN3OS2
Mol. Mass.:
366.256
SMILES:
Brc1ccc(s1)C(=O)Nc1nc(cs1)-c1ccccn1
Structure:
Search PDB for entries with ligand similarity: