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Target
ATP-dependent molecular chaperone HSP82
Ligand
BDBM64754
Substrate
n/a
Meas. Tech.
Fluorescence Cell-Based Secondary Assay of Resistant C. albicans Growth in the Presence of Fluconazole
EC50
1165±n/a nM
Citation
 PubChem, PC Fluorescence Cell-Based Secondary Assay of Resistant C. albicans Growth in the Presence of Fluconazole PubChem Bioassay (2010)[AID] 
Target
Name:
ATP-dependent molecular chaperone HSP82
Synonyms:
heat shock protein 90
Type:
Enzyme Catalytic Domain
Mol. Mass.:
80784.12
Organism:
Candida albicans
Description:
gi_994798
Residue:
707
Sequence:
MADAKVETHEFTAEISQLMSLIINTVYSNKEIFLRELISNASDALDKIRYQALSDPSQLESEPELFIRIIPQKDQKVLEIRDSGIGMTKADLVNNLGTIAKSGTKSFMEALSAGADVSMIGQFGVGFYSLFLVADHVQVISKHNDDEQYVWESNAGGKFTVTLDETNERLGRGTMLRLFLKEDQLEYLEEKRIKEVVKKHSEFVAYPIQLVVTKEVEKEVPETEEEDKAAEEDDKKPKLEEVKDEEDEKKEKKTKTVKEEVTETEELNKTKPLWTRNPSDITQDEYNAFYKSISNDWEDPLAVKHFSVEGQLEFRAILFVPKRAPFDAFESKKKKNNIKLYVRRVFITDDAEELIPEWLSFIKGVVDSEDLPLNLSREMLQQNKILKVIRKNIVKKMIETFNEISEDQEQFNQFYTAFSKNIKLGIHEDAQNRQSLAKLLRFYSTKSSEEMTSLSDYVTRMPEHQKNIYYITGESIKAVEKSPFLDALKAKNFEVLFMVDPIDEYAMTQLKEFEDKKLVDITKDFELEESDEEKAAREKEIKEYEPLTKALKDILGDQVEKVVVSYKLVDAPAAIRTGQFGWSANMERIMKAQALRDTTMSSYMSSKKTFEISPSSPIIKELKKKVETDGAEDKTVKDLTTLLFDTALLTSGFTLDEPSNFAHRINRLIALGLNIDDDSEETAVEPEATTTASTDEPAGESAMEEVD
  
Inhibitor
Name:
BDBM64754
Synonyms:
3-(2,4-dimethoxyphenyl)-4-keto-N-[2-keto-2-(4-phenylpiperazino)ethyl]phthalazine-1-carboxamide | 3-(2,4-dimethoxyphenyl)-4-oxidanylidene-N-[2-oxidanylidene-2-(4-phenylpiperazin-1-yl)ethyl]phthalazine-1-carboxamide | 3-(2,4-dimethoxyphenyl)-4-oxo-N-[2-oxo-2-(4-phenyl-1-piperazinyl)ethyl]-1-phthalazinecarboxamide | 3-(2,4-dimethoxyphenyl)-4-oxo-N-[2-oxo-2-(4-phenylpiperazin-1-yl)ethyl]phthalazine-1-carboxamide | MLS000936130 | SMR000620910 | cid_22333974
Type:
Small organic molecule
Emp. Form.:
C29H29N5O5
Mol. Mass.:
527.5711
SMILES:
COc1ccc(c(OC)c1)-n1nc(C(=O)NCC(=O)N2CCN(CC2)c2ccccc2)c2ccccc2c1=O
Structure:
Search PDB for entries with ligand similarity: