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Target
ATP-dependent molecular chaperone HSP82
Ligand
BDBM64627
Substrate
n/a
Meas. Tech.
Fluorescence Cell-Based Secondary Assay of Resistant C. albicans Growth in the Presence of Fluconazole
EC50
6148±n/a nM
Citation
 PubChem, PC Fluorescence Cell-Based Secondary Assay of Resistant C. albicans Growth in the Presence of Fluconazole PubChem Bioassay (2010)[AID] 
Target
Name:
ATP-dependent molecular chaperone HSP82
Synonyms:
heat shock protein 90
Type:
Enzyme Catalytic Domain
Mol. Mass.:
80784.12
Organism:
Candida albicans
Description:
gi_994798
Residue:
707
Sequence:
MADAKVETHEFTAEISQLMSLIINTVYSNKEIFLRELISNASDALDKIRYQALSDPSQLESEPELFIRIIPQKDQKVLEIRDSGIGMTKADLVNNLGTIAKSGTKSFMEALSAGADVSMIGQFGVGFYSLFLVADHVQVISKHNDDEQYVWESNAGGKFTVTLDETNERLGRGTMLRLFLKEDQLEYLEEKRIKEVVKKHSEFVAYPIQLVVTKEVEKEVPETEEEDKAAEEDDKKPKLEEVKDEEDEKKEKKTKTVKEEVTETEELNKTKPLWTRNPSDITQDEYNAFYKSISNDWEDPLAVKHFSVEGQLEFRAILFVPKRAPFDAFESKKKKNNIKLYVRRVFITDDAEELIPEWLSFIKGVVDSEDLPLNLSREMLQQNKILKVIRKNIVKKMIETFNEISEDQEQFNQFYTAFSKNIKLGIHEDAQNRQSLAKLLRFYSTKSSEEMTSLSDYVTRMPEHQKNIYYITGESIKAVEKSPFLDALKAKNFEVLFMVDPIDEYAMTQLKEFEDKKLVDITKDFELEESDEEKAAREKEIKEYEPLTKALKDILGDQVEKVVVSYKLVDAPAAIRTGQFGWSANMERIMKAQALRDTTMSSYMSSKKTFEISPSSPIIKELKKKVETDGAEDKTVKDLTTLLFDTALLTSGFTLDEPSNFAHRINRLIALGLNIDDDSEETAVEPEATTTASTDEPAGESAMEEVD
  
Inhibitor
Name:
BDBM64627
Synonyms:
2-N-(3,4-dimethylphenyl)-6-(4-methylpiperidin-1-yl)-5-nitropyrimidine-2,4-diamine | MLS000588548 | N*2*-(3,4-Dimethyl-phenyl)-6-(4-methyl-piperidin-1-yl)-5-nitro-pyrimidine-2,4-diamine | N2-(3,4-dimethylphenyl)-6-(4-methyl-1-piperidinyl)-5-nitropyrimidine-2,4-diamine | N2-(3,4-dimethylphenyl)-6-(4-methylpiperidin-1-yl)-5-nitro-pyrimidine-2,4-diamine | SMR000219982 | [4-amino-6-(4-methylpiperidino)-5-nitro-pyrimidin-2-yl]-(3,4-dimethylphenyl)amine | cid_3830492
Type:
Small organic molecule
Emp. Form.:
C18H24N6O2
Mol. Mass.:
356.4222
SMILES:
CC1CCN(CC1)c1nc(Nc2ccc(C)c(C)c2)nc(N)c1[N+]([O-])=O
Structure:
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