Reaction Details
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Signal transducer and activator of transcription 3 [702-738,740-752]
Ligand
BDBM68333
Substrate
n/a
Meas. Tech.
Late stage counterscreen results from the probe development effort to identify activators of signal transducer and activator of transcription 1 (STAT1)
EC50
>55690±n/a nM
Citation
PubChem, PC Late stage counterscreen results from the probe development effort to identify activators of signal transducer and activator of transcription 1 (STAT1): luminescence-based cell-based dose response assay for STAT3 activators PubChem Bioassay (2010)[AID] More Info.:
Target
Name:
Signal transducer and activator of transcription 3 [702-738,740-752]
Synonyms:
APRF | STAT3 | STAT3_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
5263.93
Organism:
Homo sapiens (Human)
Description:
gi_13272532
Residue:
50
Sequence:
AAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNGEGAEPSAGGQF
Inhibitor
Name:
BDBM68333
Synonyms:
5-methyl-3-phenyl-7-(4-pyridyl)pyrazolo[1,5-a]pyrimidine | 5-methyl-3-phenyl-7-(4-pyridyl)pyrazolo[1,5-a]pyrimidine;2,2,2-trifluoroacetic acid | 5-methyl-3-phenyl-7-pyridin-4-yl-pyrazolo[1,5-a]pyrimidine;2,2,2-tris(fluoranyl)ethanoic acid | 5-methyl-3-phenyl-7-pyridin-4-ylpyrazolo[1,5-a]pyrimidine;2,2,2-trifluoroacetic acid | SR-03000000952-1 | cid_42640810
Type:
Small organic molecule
Emp. Form.:
C18H14N4
Mol. Mass.:
286.3306
SMILES:
Cc1cc(-c2ccncc2)n2ncc(-c3ccccc3)c2n1
Structure:
