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Target
Serine/threonine-protein phosphatase
Ligand
BDBM68335
Substrate
n/a
Meas. Tech.
Fluorescence Cell-Based Secondary Assay to Identify Inhibitors of Calcineurin
EC50
>285000±n/a nM
Citation
 PubChem, PC Fluorescence Cell-Based Secondary Assay to Identify Inhibitors of Calcineurin PubChem Bioassay (2010)[AID] 
Target
Name:
Serine/threonine-protein phosphatase
Synonyms:
calcineurin A1, putative | calmodulin-binding protein 1, putative | serine/threonine-protein phosphatase 2B catalytic subunit A1, putative
Type:
Enzyme Catalytic Domain
Mol. Mass.:
69558.03
Organism:
Candida dubliniensis CD36
Description:
gi_223640082
Residue:
607
Sequence:
MSGNTVQRNTEQINNALNAIQHRRTTTGNDLNHTNQRIISQNSINDKDYTIYITDDGEKYSTVERAVKSVDPPVTFKPKDEQVFLSNGKPNHQFLKQHFIHEGRLHEHQAIQILKQATHLLSKESNLLNVPAPVTICGDVHGQYYDLMKLFEVGGDPATTKYLFLGDYVDRGSFSIECLLYLYSLKINYPDTFWMLRGNHECRHLTEYFTFKNECLHKYSEQLYEECLVSFNALPLAAIMNEQFFCVHGGLSPQLTSLDSLRKLHRFREPPTKGLMCDLLWADPIEEYDEDNIDQEYVTNVVRGCSFAFTYKAACKFLDKTKLLSVIRAHEAQNAGYRMYKRTKTMGFPSLLTMFSAPNYLDSYNNKAAVLKYENNVMNIRQFNASPHPYWLPHFMDVFTWSLPFVGEKVTDMLVSILNVCTEEELDEDLPFSESEIGVATKTTKTTTPVSPVSPKAHPPSTRITSPYKSTKLVESDNNPNTNNDDSEMTLEEKKQALRNKIIAIGKMSRMFQVLREEQENVAHLKELNRGSLPKGSLLHGVDGLKNTINSFEEAKAADRINEALPPSPEDIQRLKQEKNTRIRQQIENQEMSGPVFQRLIRRLSQS
  
Inhibitor
Name:
BDBM68335
Synonyms:
1-(4-methylphenyl)-4-oxo-2-sulfanylidene-1,3-diazaspiro[4.5]decane-3-carboxylic acid ethyl ester | 4-keto-1-(p-tolyl)-2-thioxo-1,3-diazaspiro[4.5]decane-3-carboxylic acid ethyl ester | BRD-K97464451-001-01-9 | cid_3889161 | ethyl 1-(4-methylphenyl)-4-oxidanylidene-2-sulfanylidene-1,3-diazaspiro[4.5]decane-3-carboxylate | ethyl 1-(4-methylphenyl)-4-oxo-2-sulfanylidene-1,3-diazaspiro[4.5]decane-3-carboxylate
Type:
Small organic molecule
Emp. Form.:
C18H22N2O3S
Mol. Mass.:
346.444
SMILES:
CCOC(=O)N1C(=S)N(c2ccc(C)cc2)C2(CCCCC2)C1=O
Structure:
Search PDB for entries with ligand similarity: