Reaction Details Report a problem with these data
Target
Protein Rev
Ligand
BDBM51283
Substrate
n/a
Meas. Tech.
Counterscreen for inhibitors of gld-1: Fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of the HIV Rev protein-RRE RNA interaction
IC50
18291±n/a nM
Citation
 PubChem, PC Counterscreen for inhibitors of gld-1: Fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of the HIV Rev protein-RRE RNA interaction PubChem Bioassay (2010)[AID] 
Target
Name:
Protein Rev
Synonyms:
Human immunodeficiency virus type 1 REV | REV_HV1H2 | rev
Type:
PROTEIN
Mol. Mass.:
13078.11
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_79479
Residue:
116
Sequence:
MAGRSGDSDEELIRTVRLIKLLYQSNPPPNPEGTRQARRNRRRRWRERQRQIHSISERILGTYLGRSAEPVPLQLPPLERLTLDCNEDCGTSGTQGVGSPQILVESPTVLESGTKE
  
Inhibitor
Name:
BDBM51283
Synonyms:
(1R,2R,3R,8aS)-6-Acetyl-3-carbamoyl-1-cyano-2-(4-fluoro-phenyl)-1,2,3,8a-tetrahydro-indolizine-1-car boxylic acid methyl ester | (1R,2R,3R,8aS)-6-acetyl-3-carbamoyl-1-cyano-2-(4-fluorophenyl)-3,8a-dihydro-2H-indolizine-1-carboxylic acid methyl ester | MLS001029786 | SMR000427163 | cid_11913734 | methyl (1R,2R,3R,8aS)-3-aminocarbonyl-1-cyano-6-ethanoyl-2-(4-fluorophenyl)-3,8a-dihydro-2H-indolizine-1-carboxylate | methyl (1R,2R,3R,8aS)-6-acetyl-3-carbamoyl-1-cyano-2-(4-fluorophenyl)-3,8a-dihydro-2H-indolizine-1-carboxylate
Type:
Small organic molecule
Emp. Form.:
C20H18FN3O4
Mol. Mass.:
383.373
SMILES:
COC(=O)[C@@]1(C#N)[C@@H]2C=CC(=CN2[C@H]([C@@H]1c1ccc(F)cc1)C(N)=O)C(C)=O |c:8,10|
Structure:
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