Reaction Details Report a problem with these data
Target
Heat shock factor protein 1
Ligand
BDBM39084
Substrate
n/a
Meas. Tech.
Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1)
EC50
44570±n/a nM
Citation
 PubChem, PC Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1) PubChem Bioassay (2010)[AID] 
Target
Name:
Heat shock factor protein 1
Synonyms:
HSF1_MOUSE | Hsf1 | Hsf1 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57208.68
Organism:
Mus musculus
Description:
P38532
Residue:
525
Sequence:
MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPYSAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQEPPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPALPTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTMPDMSLPDLDSSLASIQELLSPQEPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTGSSELPVLFELGESSYFSEGDDYTDDPTISLLTGTEPHKAKDPTVS
  
Inhibitor
Name:
BDBM39084
Synonyms:
3-(2-furanylmethyl)-9-methyl-N-(2-oxolanylmethyl)-4H-[1,3]thiazino[6,5-b]quinolin-2-imine | 3-(furan-2-ylmethyl)-9-methyl-N-(oxolan-2-ylmethyl)-4H-[1,3]thiazino[6,5-b]quinolin-2-imine | MLS000032944 | SMR000005542 | [3-(2-furfuryl)-9-methyl-4H-[1,3]thiazino[6,5-b]quinolin-2-ylidene]-(tetrahydrofurfuryl)amine | [3-Furan-2-ylmethyl-8-methyl-3,4-dihydro-1-thia-3,9-diaza-anthracen-(2E)-ylidene]-(tetrahydro-furan-2-ylmethyl)-amine | cid_653192
Type:
Small organic molecule
Emp. Form.:
C22H23N3O2S
Mol. Mass.:
393.502
SMILES:
Cc1cccc2cc3CN(Cc4ccco4)\C(Sc3nc12)=N\CC1CCCO1
Structure:
Search PDB for entries with ligand similarity: