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Target
Eukaryotic translation initiation factor 4H
Ligand
BDBM73150
Substrate
n/a
Meas. Tech.
SAR analysis for the identification of translation initiation inhibitors (eIF4H)
IC50
>100000±n/a nM
Citation
 PubChem, PC SAR analysis for the identification of translation initiation inhibitors (eIF4H) PubChem Bioassay (2010)[AID] 
Target
Name:
Eukaryotic translation initiation factor 4H
Synonyms:
EIF4H | IF4H_HUMAN | KIAA0038 | WBSCR1 | WSCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27385.24
Organism:
Homo sapiens (Human)
Description:
Q15056
Residue:
248
Sequence:
MADFDTYDDRAYSSFGGGRGSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGMGSSRESRGGWDSRDDFNSGFRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPPLRGSNMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPREEVVQKEQE
  
Inhibitor
Name:
BDBM73150
Synonyms:
4-(2-ketopyrrolidino)benzoic acid [2-keto-2-(2-methoxy-4-nitro-anilino)ethyl] ester | 4-(2-oxo-1-pyrrolidinyl)benzoic acid [2-(2-methoxy-4-nitroanilino)-2-oxoethyl] ester | MLS-0435517.0001 | [2-(2-methoxy-4-nitroanilino)-2-oxoethyl] 4-(2-oxopyrrolidin-1-yl)benzoate | [2-[(2-methoxy-4-nitro-phenyl)amino]-2-oxidanylidene-ethyl] 4-(2-oxidanylidenepyrrolidin-1-yl)benzoate | cid_3895856
Type:
Small organic molecule
Emp. Form.:
C20H19N3O7
Mol. Mass.:
413.3808
SMILES:
COc1cc(ccc1NC(=O)COC(=O)c1ccc(cc1)N1CCCC1=O)[N+]([O-])=O
Structure:
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