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Target
Eukaryotic translation initiation factor 4H
Ligand
BDBM73154
Substrate
n/a
Meas. Tech.
SAR analysis for the identification of translation initiation inhibitors (eIF4H)
IC50
>100000±n/a nM
Citation
 PubChem, PC SAR analysis for the identification of translation initiation inhibitors (eIF4H) PubChem Bioassay (2010)[AID] 
Target
Name:
Eukaryotic translation initiation factor 4H
Synonyms:
EIF4H | IF4H_HUMAN | KIAA0038 | WBSCR1 | WSCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27385.24
Organism:
Homo sapiens (Human)
Description:
Q15056
Residue:
248
Sequence:
MADFDTYDDRAYSSFGGGRGSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGMGSSRESRGGWDSRDDFNSGFRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPPLRGSNMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPREEVVQKEQE
  
Inhibitor
Name:
BDBM73154
Synonyms:
4-(carbamoylamino)benzoic acid [2-(5-chloro-2-methoxyanilino)-2-oxoethyl] ester | 4-ureidobenzoic acid [2-(5-chloro-2-methoxy-anilino)-2-keto-ethyl] ester | MLS-0435521.0001 | [2-(5-chloro-2-methoxyanilino)-2-oxoethyl] 4-(carbamoylamino)benzoate | [2-[(5-chloranyl-2-methoxy-phenyl)amino]-2-oxidanylidene-ethyl] 4-(aminocarbonylamino)benzoate | cid_2116587
Type:
Small organic molecule
Emp. Form.:
C17H16ClN3O5
Mol. Mass.:
377.779
SMILES:
COc1ccc(Cl)cc1NC(=O)COC(=O)c1ccc(NC(N)=O)cc1
Structure:
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