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Target
Eukaryotic translation initiation factor 4H
Ligand
BDBM73158
Substrate
n/a
Meas. Tech.
SAR analysis for the identification of translation initiation inhibitors (eIF4H)
IC50
>100000±n/a nM
Citation
 PubChem, PC SAR analysis for the identification of translation initiation inhibitors (eIF4H) PubChem Bioassay (2010)[AID] 
Target
Name:
Eukaryotic translation initiation factor 4H
Synonyms:
EIF4H | IF4H_HUMAN | KIAA0038 | WBSCR1 | WSCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27385.24
Organism:
Homo sapiens (Human)
Description:
Q15056
Residue:
248
Sequence:
MADFDTYDDRAYSSFGGGRGSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGMGSSRESRGGWDSRDDFNSGFRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPPLRGSNMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPREEVVQKEQE
  
Inhibitor
Name:
BDBM73158
Synonyms:
2-(4-chlorobenzoyl)benzoic acid [2-keto-2-(2-methoxy-5-nitro-anilino)-1-methyl-ethyl] ester | 2-[(4-chlorophenyl)-oxomethyl]benzoic acid [1-(2-methoxy-5-nitroanilino)-1-oxopropan-2-yl] ester | MLS-0211561.0001 | [1-(2-methoxy-5-nitroanilino)-1-oxopropan-2-yl] 2-(4-chlorobenzoyl)benzoate | [1-[(2-methoxy-5-nitro-phenyl)amino]-1-oxidanylidene-propan-2-yl] 2-(4-chlorophenyl)carbonylbenzoate | cid_4213000
Type:
Small organic molecule
Emp. Form.:
C24H19ClN2O7
Mol. Mass.:
482.87
SMILES:
COc1ccc(cc1NC(=O)C(C)OC(=O)c1ccccc1C(=O)c1ccc(Cl)cc1)[N+]([O-])=O
Structure:
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