Reaction Details Report a problem with these data
Target
Eukaryotic translation initiation factor 4H
Ligand
BDBM53193
Substrate
n/a
Meas. Tech.
SAR analysis for the identification of translation initiation inhibitors (eIF4H)
IC50
1140±n/a nM
Citation
 PubChem, PC SAR analysis for the identification of translation initiation inhibitors (eIF4H) PubChem Bioassay (2010)[AID] 
Target
Name:
Eukaryotic translation initiation factor 4H
Synonyms:
EIF4H | IF4H_HUMAN | KIAA0038 | WBSCR1 | WSCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27385.24
Organism:
Homo sapiens (Human)
Description:
Q15056
Residue:
248
Sequence:
MADFDTYDDRAYSSFGGGRGSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGMGSSRESRGGWDSRDDFNSGFRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPPLRGSNMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPREEVVQKEQE
  
Inhibitor
Name:
BDBM53193
Synonyms:
4-tert-butyl-N-(5-quinolinyl)benzamide | 4-tert-butyl-N-(5-quinolyl)benzamide | 4-tert-butyl-N-quinolin-5-yl-benzamide | 4-tert-butyl-N-quinolin-5-ylbenzamide | MLS001233705 | SMR000596113 | cid_2103217
Type:
Small organic molecule
Emp. Form.:
C20H20N2O
Mol. Mass.:
304.3856
SMILES:
CC(C)(C)c1ccc(cc1)C(=O)Nc1cccc2ncccc12
Structure:
Search PDB for entries with ligand similarity: