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Target
Eukaryotic translation initiation factor 4H
Ligand
BDBM44753
Substrate
n/a
Meas. Tech.
SAR analysis for the identification of translation initiation inhibitors (eIF4H)
IC50
5420±n/a nM
Citation
 PubChem, PC SAR analysis for the identification of translation initiation inhibitors (eIF4H) PubChem Bioassay (2010)[AID] 
Target
Name:
Eukaryotic translation initiation factor 4H
Synonyms:
EIF4H | IF4H_HUMAN | KIAA0038 | WBSCR1 | WSCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27385.24
Organism:
Homo sapiens (Human)
Description:
Q15056
Residue:
248
Sequence:
MADFDTYDDRAYSSFGGGRGSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGMGSSRESRGGWDSRDDFNSGFRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPPLRGSNMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPREEVVQKEQE
  
Inhibitor
Name:
BDBM44753
Synonyms:
MLS000117135 | N-[3-(2-furyl)-1-methyl-propyl]-3-keto-2-(4-methoxyphenyl)isoindoline-4-carboxamide | N-[4-(2-furanyl)butan-2-yl]-2-(4-methoxyphenyl)-3-oxo-1H-isoindole-4-carboxamide | N-[4-(furan-2-yl)butan-2-yl]-2-(4-methoxyphenyl)-3-oxidanylidene-1H-isoindole-4-carboxamide | N-[4-(furan-2-yl)butan-2-yl]-2-(4-methoxyphenyl)-3-oxo-1H-isoindole-4-carboxamide | SMR000094088 | cid_5309709
Type:
Small organic molecule
Emp. Form.:
C24H24N2O4
Mol. Mass.:
404.4584
SMILES:
COc1ccc(cc1)N1Cc2cccc(C(=O)NC(C)CCc3ccco3)c2C1=O
Structure:
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