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Target
Eukaryotic translation initiation factor 4H
Ligand
BDBM40089
Substrate
n/a
Meas. Tech.
SAR analysis for the identification of translation initiation inhibitors (eIF4H)
IC50
1430±n/a nM
Citation
 PubChem, PC SAR analysis for the identification of translation initiation inhibitors (eIF4H) PubChem Bioassay (2010)[AID] 
Target
Name:
Eukaryotic translation initiation factor 4H
Synonyms:
EIF4H | IF4H_HUMAN | KIAA0038 | WBSCR1 | WSCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27385.24
Organism:
Homo sapiens (Human)
Description:
Q15056
Residue:
248
Sequence:
MADFDTYDDRAYSSFGGGRGSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGMGSSRESRGGWDSRDDFNSGFRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPPLRGSNMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPREEVVQKEQE
  
Inhibitor
Name:
BDBM40089
Synonyms:
7-[4-(2-furoyl)piperazine-1-carbonyl]-2-(4-methoxyphenyl)isoindolin-1-one | 7-[4-(furan-2-carbonyl)piperazine-1-carbonyl]-2-(4-methoxyphenyl)-3H-isoindol-1-one | 7-[4-(furan-2-ylcarbonyl)piperazin-1-yl]carbonyl-2-(4-methoxyphenyl)-3H-isoindol-1-one | 7-[[4-[2-furanyl(oxo)methyl]-1-piperazinyl]-oxomethyl]-2-(4-methoxyphenyl)-3H-isoindol-1-one | MLS000117134 | SMR000094087 | cid_5307358
Type:
Small organic molecule
Emp. Form.:
C25H23N3O5
Mol. Mass.:
445.4672
SMILES:
COc1ccc(cc1)N1Cc2cccc(C(=O)N3CCN(CC3)C(=O)c3ccco3)c2C1=O
Structure:
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