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Target
Eukaryotic translation initiation factor 4H
Ligand
BDBM73182
Substrate
n/a
Meas. Tech.
SAR analysis for the identification of translation initiation inhibitors (eIF4H)
IC50
>100000±n/a nM
Citation
 PubChem, PC SAR analysis for the identification of translation initiation inhibitors (eIF4H) PubChem Bioassay (2010)[AID] 
Target
Name:
Eukaryotic translation initiation factor 4H
Synonyms:
EIF4H | IF4H_HUMAN | KIAA0038 | WBSCR1 | WSCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27385.24
Organism:
Homo sapiens (Human)
Description:
Q15056
Residue:
248
Sequence:
MADFDTYDDRAYSSFGGGRGSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGMGSSRESRGGWDSRDDFNSGFRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPPLRGSNMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPREEVVQKEQE
  
Inhibitor
Name:
BDBM73182
Synonyms:
4-keto-N-(4-methoxyphenyl)-2-(2-methoxyphenyl)imino-3-methyl-1,3-thiazinane-6-carboxamide | MLS-0435564.0001 | N-(4-methoxyphenyl)-2-(2-methoxyphenyl)imino-3-methyl-4-oxidanylidene-1,3-thiazinane-6-carboxamide | N-(4-methoxyphenyl)-2-(2-methoxyphenyl)imino-3-methyl-4-oxo-1,3-thiazinane-6-carboxamide | cid_3139920
Type:
Small organic molecule
Emp. Form.:
C20H21N3O4S
Mol. Mass.:
399.463
SMILES:
COc1ccc(NC(=O)C2CC(=O)N(C)\C(S2)=N\c2ccccc2OC)cc1
Structure:
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