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Target
Eukaryotic translation initiation factor 4H
Ligand
BDBM73194
Substrate
n/a
Meas. Tech.
SAR analysis for the identification of translation initiation inhibitors (eIF4H)
IC50
>100000±n/a nM
Citation
 PubChem, PC SAR analysis for the identification of translation initiation inhibitors (eIF4H) PubChem Bioassay (2010)[AID] 
Target
Name:
Eukaryotic translation initiation factor 4H
Synonyms:
EIF4H | IF4H_HUMAN | KIAA0038 | WBSCR1 | WSCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27385.24
Organism:
Homo sapiens (Human)
Description:
Q15056
Residue:
248
Sequence:
MADFDTYDDRAYSSFGGGRGSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGMGSSRESRGGWDSRDDFNSGFRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPPLRGSNMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPREEVVQKEQE
  
Inhibitor
Name:
BDBM73194
Synonyms:
2-[6-(furan-2-yl)pyridazin-3-yl]sulfanyl-N-[2-(2-methoxyphenyl)ethyl]acetamide | 2-[6-(furan-2-yl)pyridazin-3-yl]sulfanyl-N-[2-(2-methoxyphenyl)ethyl]ethanamide | 2-[[6-(2-furanyl)-3-pyridazinyl]thio]-N-[2-(2-methoxyphenyl)ethyl]acetamide | 2-[[6-(2-furyl)pyridazin-3-yl]thio]-N-[2-(2-methoxyphenyl)ethyl]acetamide | MLS-0241469.0001 | cid_6624223
Type:
Small organic molecule
Emp. Form.:
C19H19N3O3S
Mol. Mass.:
369.437
SMILES:
COc1ccccc1CCNC(=O)CSc1ccc(nn1)-c1ccco1
Structure:
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