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Target
ATP-sensitive inward rectifier potassium channel 1
Ligand
BDBM73213
Substrate
n/a
Meas. Tech.
High throughput discovery of novel modulators of ROMK K+ channel activity: Analog Library Testing
IC50
6528±n/a nM
Citation
 PubChem, PC High throughput discovery of novel modulators of ROMK K+ channel activity: Analog Library Testing PubChem Bioassay (2010)[AID] 
Target
Name:
ATP-sensitive inward rectifier potassium channel 1
Synonyms:
ATP-regulated potassium channel ROM-K | ATP-regulated potassium channel ROMK | ATP-sensitive inward rectifier potassium channel 1 | Egl nine homolog 1 | KCNJ1 | KCNJ1_HUMAN | Potassium channel (ATP modulatory) | Potassium inwardly-rectifying channel, subfamily J, member 1 | ROMK1 | Renal Outer Medullary Potassium (ROMK1) | The Renal Outer Medullary Potassium (ROMK)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44809.08
Organism:
Homo sapiens (Human)
Description:
gi_223460826
Residue:
391
Sequence:
MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCNIEFGNVEAQSRFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFHPSANHTPCVENINGLTSAFLFSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILAKISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGETIILDQININFVVDAGNENLFFISPLTIYHVIDHNSPFFHMAAETLLQQDFELVVFLDGTVESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEVETPHCAMCLYNEKDVRARMKRGYDNPNFILSEVNETDDTKM
  
Inhibitor
Name:
BDBM73213
Synonyms:
6-nitro-2-[3-(6-nitro-1H-benzimidazol-2-yl)propyl]-1H-benzimidazole | VU0288367-6 | cid_3096126
Type:
Small organic molecule
Emp. Form.:
C17H14N6O4
Mol. Mass.:
366.3309
SMILES:
[O-][N+](=O)c1ccc2nc(CCCc3nc4ccc(cc4[nH]3)[N+]([O-])=O)[nH]c2c1
Structure:
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