Target
ATP-sensitive inward rectifier potassium channel 1
Ligand
BDBM73214
Substrate
n/a
Meas. Tech.
High throughput discovery of novel modulators of ROMK K+ channel activity: Analog Library Testing
IC50
1500±n/a nM
Citation
 PubChem, PC High throughput discovery of novel modulators of ROMK K+ channel activity: Analog Library Testing PubChem Bioassay (2010)[AID] 
Target
Name:
ATP-sensitive inward rectifier potassium channel 1
Synonyms:
ATP-regulated potassium channel ROM-K | ATP-regulated potassium channel ROMK | ATP-sensitive inward rectifier potassium channel 1 | Egl nine homolog 1 | KCNJ1 | KCNJ1_HUMAN | Potassium channel (ATP modulatory) | Potassium inwardly-rectifying channel, subfamily J, member 1 | ROMK1 | Renal Outer Medullary Potassium (ROMK1) | The Renal Outer Medullary Potassium (ROMK)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44809.08
Organism:
Homo sapiens (Human)
Description:
gi_223460826
Residue:
391
Sequence:
MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCNIEFGNVEAQSRFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFHPSANHTPCVENINGLTSAFLFSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILAKISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGETIILDQININFVVDAGNENLFFISPLTIYHVIDHNSPFFHMAAETLLQQDFELVVFLDGTVESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEVETPHCAMCLYNEKDVRARMKRGYDNPNFILSEVNETDDTKM
  
Inhibitor
Name:
BDBM73214
Synonyms:
7-(2-methoxy-4-nitro-benzyl)-13-(2-methoxy-5-nitro-benzyl)-1,4,10-trioxa-7,13-diazacyclopentadecane;2,2,2-trifluoroacetic acid | 7-[(2-methoxy-4-nitro-phenyl)methyl]-13-[(2-methoxy-5-nitro-phenyl)methyl]-1,4,10-trioxa-7,13-diazacyclopentadecane;2,2,2-tris(fluoranyl)ethanoic acid | 7-[(2-methoxy-4-nitrophenyl)methyl]-13-[(2-methoxy-5-nitrophenyl)methyl]-1,4,10-trioxa-7,13-diazacyclopentadecane;2,2,2-trifluoroacetic acid | VU0402610-1 | cid_44176370
Type:
Small organic molecule
Emp. Form.:
C26H36N4O9
Mol. Mass.:
548.5854
SMILES:
COc1ccc(cc1CN1CCOCCOCCN(Cc2ccc(cc2OC)[N+]([O-])=O)CCOCC1)[N+]([O-])=O
Structure:
Search PDB for entries with ligand similarity: