Target
Polyadenylate-binding protein 1
Ligand
BDBM40089
Substrate
n/a
Meas. Tech.
SAR analysis for the identification of translation initiation inhibitors (PABP)
IC50
10200±n/a nM
Citation
 PubChem, PC SAR analysis for the identification of translation initiation inhibitors (PABP) PubChem Bioassay (2010)[AID] 
Target
Name:
Polyadenylate-binding protein 1
Synonyms:
PAB1 | PABP | PABP1 | PABP1_HUMAN | PABPC1 | PABPC2 | poly(A) binding protein, cytoplasmic 1 | polyadenylate-binding protein 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
70694.26
Organism:
Homo sapiens (Human)
Description:
gi_46367787
Residue:
636
Sequence:
MNPSAPSYPMASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYGFVHFETQEAAERAIEKMNGMLLNDRKVFVGRFKSRKEREAELGARAKEFTNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYFMAAIPQTQNRAAYYPPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQRVANTSTQTMGPRPAAAAAAATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHQAKEAAQKAVNSATGVPTV
  
Inhibitor
Name:
BDBM40089
Synonyms:
7-[4-(2-furoyl)piperazine-1-carbonyl]-2-(4-methoxyphenyl)isoindolin-1-one | 7-[4-(furan-2-carbonyl)piperazine-1-carbonyl]-2-(4-methoxyphenyl)-3H-isoindol-1-one | 7-[4-(furan-2-ylcarbonyl)piperazin-1-yl]carbonyl-2-(4-methoxyphenyl)-3H-isoindol-1-one | 7-[[4-[2-furanyl(oxo)methyl]-1-piperazinyl]-oxomethyl]-2-(4-methoxyphenyl)-3H-isoindol-1-one | MLS000117134 | SMR000094087 | cid_5307358
Type:
Small organic molecule
Emp. Form.:
C25H23N3O5
Mol. Mass.:
445.4672
SMILES:
COc1ccc(cc1)N1Cc2cccc(C(=O)N3CCN(CC3)C(=O)c3ccco3)c2C1=O
Structure:
Search PDB for entries with ligand similarity: