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Target
Polyadenylate-binding protein 1
Ligand
BDBM63377
Substrate
n/a
Meas. Tech.
SAR analysis for the identification of translation initiation inhibitors (PABP)
IC50
>100000±n/a nM
Citation
 PubChem, PC SAR analysis for the identification of translation initiation inhibitors (PABP) PubChem Bioassay (2010)[AID] 
Target
Name:
Polyadenylate-binding protein 1
Synonyms:
PAB1 | PABP | PABP1 | PABP1_HUMAN | PABPC1 | PABPC2 | poly(A) binding protein, cytoplasmic 1 | polyadenylate-binding protein 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
70694.26
Organism:
Homo sapiens (Human)
Description:
gi_46367787
Residue:
636
Sequence:
MNPSAPSYPMASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYGFVHFETQEAAERAIEKMNGMLLNDRKVFVGRFKSRKEREAELGARAKEFTNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYFMAAIPQTQNRAAYYPPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQRVANTSTQTMGPRPAAAAAAATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHQAKEAAQKAVNSATGVPTV
  
Inhibitor
Name:
BDBM63377
Synonyms:
2-[6-(furan-2-yl)pyridazin-3-yl]sulfanyl-N-[2-(4-methoxyphenyl)ethyl]acetamide | 2-[6-(furan-2-yl)pyridazin-3-yl]sulfanyl-N-[2-(4-methoxyphenyl)ethyl]ethanamide | 2-[[6-(2-furanyl)-3-pyridazinyl]thio]-N-[2-(4-methoxyphenyl)ethyl]acetamide | 2-[[6-(2-furyl)pyridazin-3-yl]thio]-N-[2-(4-methoxyphenyl)ethyl]acetamide | MLS000678487 | SMR000323965 | cid_7207272
Type:
Small organic molecule
Emp. Form.:
C19H19N3O3S
Mol. Mass.:
369.437
SMILES:
COc1ccc(CCNC(=O)CSc2ccc(nn2)-c2ccco2)cc1
Structure:
Search PDB for entries with ligand similarity: