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Target
Polyadenylate-binding protein 1
Ligand
BDBM73196
Substrate
n/a
Meas. Tech.
SAR analysis for the identification of translation initiation inhibitors (PABP)
IC50
>100000±n/a nM
Citation
 PubChem, PC SAR analysis for the identification of translation initiation inhibitors (PABP) PubChem Bioassay (2010)[AID] 
Target
Name:
Polyadenylate-binding protein 1
Synonyms:
PAB1 | PABP | PABP1 | PABP1_HUMAN | PABPC1 | PABPC2 | poly(A) binding protein, cytoplasmic 1 | polyadenylate-binding protein 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
70694.26
Organism:
Homo sapiens (Human)
Description:
gi_46367787
Residue:
636
Sequence:
MNPSAPSYPMASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYGFVHFETQEAAERAIEKMNGMLLNDRKVFVGRFKSRKEREAELGARAKEFTNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYFMAAIPQTQNRAAYYPPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQRVANTSTQTMGPRPAAAAAAATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHQAKEAAQKAVNSATGVPTV
  
Inhibitor
Name:
BDBM73196
Synonyms:
1-(1-azepanyl)-2-[[6-(2-furanyl)-3-pyridazinyl]thio]ethanone | 1-(azepan-1-yl)-2-[6-(furan-2-yl)pyridazin-3-yl]sulfanyl-ethanone | 1-(azepan-1-yl)-2-[6-(furan-2-yl)pyridazin-3-yl]sulfanylethanone | 1-(azepan-1-yl)-2-[[6-(2-furyl)pyridazin-3-yl]thio]ethanone | MLS-0246034.0001 | cid_7207196
Type:
Small organic molecule
Emp. Form.:
C16H19N3O2S
Mol. Mass.:
317.406
SMILES:
O=C(CSc1ccc(nn1)-c1ccco1)N1CCCCCC1
Structure:
Search PDB for entries with ligand similarity: