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Target
Protein LANA1
Ligand
BDBM73377
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Cell-Free Homogeneous Dose Retest to Confirm Inhibitors of the LANA Histone H2A/H2B Interaction
EC50
>75000±n/a nM
Citation
 PubChem, PC Fluorescence Polarization Cell-Free Homogeneous Dose Retest to Confirm Inhibitors of the LANA Histone H2A/H2B Interaction PubChem Bioassay (2010)[AID] 
Target
Name:
Protein LANA1
Synonyms:
LANA | LANA1 | LANA1_HHV8P
Type:
Enzyme Catalytic Domain
Mol. Mass.:
131093.36
Organism:
Human herpesvirus 8
Description:
Q9QR71
Residue:
1129
Sequence:
MAPPGMRLRSGRSTGAPLTRGSCRKRNRSPERCDLGDDLHLQPRRKHVADSVDGRECGPHTLPIPGSPTVFTSGLPAFVSSPTLPVAPIPSPAPATPLPPPALLPPVTTSSSPIPPSHPVSPGTTDTHSPSPALPPTQSPESSQRPPLSSPTGRPDSSTPMRPPPSQQTTPPHSPTTPPPEPPSKSSPDSLAPSTLRSLRKRRLSSPQGPSTLNPICQSPPVSPPRCDFANRSVYPPWATESPIYVGSSSDGDTPPRQPPTSPISIGSSSPSEGSWGDDTAMLVLLAEIAEEASKNEKECSENNQAGEDNGDNEISKESQVDKDDNDNKDDEEEQETDEEDEEDDEEDDEEDDEEDDEEDDEEDDEEDDEEEDEEEDEEEDEEEDEEEEEDEEDDDDEDNEDEEDDEEEDKKEDEEDGGDGNKTLSIQSSQQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQREPQQREPQQREPQQREPQQREPQQREPQQREPQQREPQQREPQQREPQQREPQQREPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQDEQQQDEQQQDEQQQDEQQQDEQQQDEQQQDEQQQDEQEQQDEQQQDEQQQQDEQEQQEEQEQQEEQQQDEQQQDEQQQDEQQQDEQEQQDEQQQDEQQQQDEQEQQEEQEQQEEQEQQEEQEQQEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQEQELEEVEEQEQEQEEQELEEVEEQEQEQEEQEEQELEEVEEQEEQELEEVEEQEEQELEEVEEQEQQGVEQQEQETVEEPIILHGSSSEDEMEVDYPVVSTHEQIASSPPGDNTPDDDPQPGPSREYRYVLRTSPPHRPGVRMRRVPVTHPKKPHPRYQQPPVPYRQIDDCPAKARPQHIFYRRFLGKDGRRDPKCQWKFAVIFWGNDPYGLKKLSQAFQFGGVKAGPVSCLPHPGPDQSPITYCVYVYCQNKDTSKKVQMARLAWEASHPLAGNLQSSIVKFKKPLPLTQPGENQGPGDSPQEMT
  
Inhibitor
Name:
BDBM73377
Synonyms:
4-(1,3-dioxo-2-isoindolyl)-N-(2-furanylmethyl)-1-cyclohexanecarboxamide | 4-(1,3-dioxoisoindol-2-yl)-N-(furan-2-ylmethyl)cyclohexane-1-carboxamide | 4-[1,3-bis(oxidanylidene)isoindol-2-yl]-N-(furan-2-ylmethyl)cyclohexane-1-carboxamide | MLS000112427 | N-(2-furfuryl)-4-phthalimido-cyclohexanecarboxamide | SMR000108341 | cid_1164668
Type:
Small organic molecule
Emp. Form.:
C20H20N2O4
Mol. Mass.:
352.3838
SMILES:
O=C(NCc1ccco1)C1CCC(CC1)N1C(=O)c2ccccc2C1=O |(15.03,2.53,;14.26,1.2,;15.03,-.13,;16.57,-.13,;17.34,-1.47,;18.88,-1.63,;19.2,-3.13,;17.86,-3.9,;16.72,-2.87,;12.72,1.2,;11.95,-.13,;10.41,-.13,;9.64,1.2,;10.41,2.53,;11.95,2.53,;8.1,1.2,;7.2,2.44,;7.68,3.9,;5.75,1.97,;4.41,2.74,;3.08,1.97,;3.08,.43,;4.41,-.34,;5.75,.43,;7.2,-.04,;7.68,-1.5,)|
Structure:
Search PDB for entries with ligand similarity: