Reaction Details Report a problem with these data
Target
Tyrosine-protein phosphatase non-receptor type 22
Ligand
BDBM74537
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits from a small molecule inhibitors of LYP via a fluorescence intensity assay - Set 2
IC50
>79400±0 nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits from a small molecule inhibitors of LYP via a fluorescence intensity assay - Set 2 PubChem Bioassay (2010)[AID] 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 22
Synonyms:
3.1.3.48 | Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP | LyP | Lymphoid phosphatase | Lymphoid phosphatase (Lyp) | PEP | PEST-domain phosphatase | PTN22_HUMAN | PTPN22 | PTPN8 | Tyrosine-protein phosphatase non-receptor type 22 (LYP) | tyrosine-protein phosphatase non-receptor type 22 isoform 1
Type:
n/a
Mol. Mass.:
91712.31
Organism:
Homo sapiens (Human)
Description:
Q9Y2R2
Residue:
807
Sequence:
MDQREILQKFLDEAQSKKITKEEFANEFLKLKRQSTKYKADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPGEMQLEFGPFSVSCEAEKRKSDYIIRTLKVKFNSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQEDDSVPICIHCSAGCGRTGVICAIDYTWMLLKDGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKRQMDVIRDKHSGTESQAKHCIPEKNHTLQADSYSPNLPKSTTKAAKMMNQQRTKMEIKESSSFDFRTSEISAKEELVLHPAKSSTSFDFLELNYSFDKNADTTMKWQTKAFPIVGEPLQKHQSLDLGSLLFEGCSNSKPVNAAGRYFNSKVPITRTKSTPFELIQQRETKEVDSKENFSYLESQPHDSCFVEMQAQKVMHVSSAELNYSLPYDSKHQIRNASNVKHHDSSALGVYSYIPLVENPYFSSWPPSGTSSKMSLDLPEKQDGTVFPSSLLPTSSTSLFSYYNSHDSLSLNSPTNISSLLNQESAVLATAPRIDDEIPPPLPVRTPESFIVVEEAGEFSPNVPKSLSSAVKVKIGTSLEWGGTSEPKKFDDSVILRPSKSVKLRSPKSELHQDRSSPPPPLPERTLESFFLADEDCMQAQSIETYSTSYPDTMENSTSSKQTLKTPGKSFTRSKSLKILRNMKKSICNSCPPNKPAESVQSNNSSSFLNFGFANRFSKPKGPRNPPPTWNI
  
Inhibitor
Name:
BDBM74537
Synonyms:
2-[1-[[5-[(5-chloro-3-pyridyl)oxymethyl]isoxazole-3-carbonyl]amino]cyclohexyl]acetic acid ethyl ester | 2-[1-[[[5-[(5-chloro-3-pyridinyl)oxymethyl]-3-isoxazolyl]-oxomethyl]amino]cyclohexyl]acetic acid ethyl ester | MLS001106081 | SMR000659027 | cid_24791537 | ethyl 2-[1-[[5-[(5-chloranylpyridin-3-yl)oxymethyl]-1,2-oxazol-3-yl]carbonylamino]cyclohexyl]ethanoate | ethyl 2-[1-[[5-[(5-chloropyridin-3-yl)oxymethyl]-1,2-oxazole-3-carbonyl]amino]cyclohexyl]acetate
Type:
Small organic molecule
Emp. Form.:
C20H24ClN3O5
Mol. Mass.:
421.875
SMILES:
CCOC(=O)CC1(CCCCC1)NC(=O)c1cc(COc2cncc(Cl)c2)on1
Structure:
Search PDB for entries with ligand similarity: