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Target
Importin subunit alpha-1
Ligand
BDBM74602
Substrate
n/a
Meas. Tech.
Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex.
EC50
>500000±n/a nM
Citation
 PubChem, PC Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex. PubChem Bioassay (2010)[AID] 
Target
Name:
Importin subunit alpha-1
Synonyms:
IMA1_HUMAN | KPNA2 | RCH1 | SRP1 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57852.15
Organism:
Homo sapiens (Human)
Description:
gi_119609447
Residue:
529
Sequence:
MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF
  
Inhibitor
Name:
BDBM74602
Synonyms:
2-amino-4-(3-chlorophenyl)-6-cyclopropyl-5-keto-7-methyl-4H-pyrano[3,2-c]pyridine-3-carbonitrile | 2-amino-4-(3-chlorophenyl)-6-cyclopropyl-7-methyl-5-oxo-4H-pyrano[3,2-c]pyridine-3-carbonitrile | 2-azanyl-4-(3-chlorophenyl)-6-cyclopropyl-7-methyl-5-oxidanylidene-4H-pyrano[3,2-c]pyridine-3-carbonitrile | MLS000084517 | SMR000047423 | cid_666086
Type:
Small organic molecule
Emp. Form.:
C19H16ClN3O2
Mol. Mass.:
353.802
SMILES:
Cc1cc2OC(=N)C(C#N)C(c3cccc(Cl)c3)c2c(=O)n1C1CC1
Structure:
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