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Target
Importin subunit alpha-1
Ligand
BDBM42770
Substrate
n/a
Meas. Tech.
Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex.
EC50
>500000±n/a nM
Citation
PubChem, PC Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex. PubChem Bioassay (2010)[AID]
More Info.:
Target
Name:
Importin subunit alpha-1
Synonyms:
IMA1_HUMAN | KPNA2 | RCH1 | SRP1 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57852.15
Organism:
Homo sapiens (Human)
Description:
gi_119609447
Residue:
529
Sequence:
MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF
Inhibitor
Name:
BDBM42770
Synonyms:
3-[(5-methylthiophene-3-carbonyl)amino]thiophene-2-carboxylic acid methyl ester | 3-[[(5-methyl-3-thiophenyl)-oxomethyl]amino]-2-thiophenecarboxylic acid methyl ester | MLS000065788 | SMR000080473 | cid_1245967 | methyl 3-[(5-methylthiophen-3-yl)carbonylamino]thiophene-2-carboxylate | methyl 3-[(5-methylthiophene-3-carbonyl)amino]thiophene-2-carboxylate | methyl 3-{[(5-methyl-3-thienyl)carbonyl]amino}-2-thiophenecarboxylate
Type:
Small organic molecule
Emp. Form.:
C12H11NO3S2
Mol. Mass.:
281.351
SMILES:
COC(=O)c1sccc1NC(=O)c1csc(C)c1