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Target
Kappa-type opioid receptor
Ligand
BDBM75399
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule agonists of the kappa opioid receptor via a luminescent beta-arrestin assay - Set 3
EC50
3040±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule agonists of the kappa opioid receptor via a luminescent beta-arrestin assay - Set 3 PubChem Bioassay (2010)[AID] 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM75399
Synonyms:
2-[4-(2-thenyl)-5-[(2,3,4-trifluorobenzyl)thio]-1,2,4-triazol-3-yl]pyridine | 2-[4-(thiophen-2-ylmethyl)-5-[(2,3,4-trifluorophenyl)methylsulfanyl]-1,2,4-triazol-3-yl]pyridine | 2-[4-(thiophen-2-ylmethyl)-5-[(2,3,4-trifluorophenyl)methylthio]-1,2,4-triazol-3-yl]pyridine | 2-[4-(thiophen-2-ylmethyl)-5-[[2,3,4-tris(fluoranyl)phenyl]methylsulfanyl]-1,2,4-triazol-3-yl]pyridine | KSC-5-289F12 | KUC104203N | cid_44620921
Type:
Small organic molecule
Emp. Form.:
C19H13F3N4S2
Mol. Mass.:
418.459
SMILES:
Fc1ccc(CSc2nnc(-c3ccccn3)n2Cc2cccs2)c(F)c1F
Structure:
Search PDB for entries with ligand similarity: