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Target
Kappa-type opioid receptor
Ligand
BDBM75414
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule agonists of the kappa opioid receptor via a luminescent beta-arrestin assay - Set 3
EC50
>20000±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule agonists of the kappa opioid receptor via a luminescent beta-arrestin assay - Set 3 PubChem Bioassay (2010)[AID] 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM75414
Synonyms:
2-[5-(benzylthio)-4-(3-pyridylmethyl)-1,2,4-triazol-3-yl]pyridine | 2-[5-(phenylmethylsulfanyl)-4-(pyridin-3-ylmethyl)-1,2,4-triazol-3-yl]pyridine | 2-[5-(phenylmethylthio)-4-(3-pyridinylmethyl)-1,2,4-triazol-3-yl]pyridine | 2-[5-benzylsulfanyl-4-(pyridin-3-ylmethyl)-1,2,4-triazol-3-yl]pyridine | KSC-12-171-A4 | KUC105576N | cid_45479177
Type:
Small organic molecule
Emp. Form.:
C20H17N5S
Mol. Mass.:
359.447
SMILES:
C(Sc1nnc(-c2ccccn2)n1Cc1cccnc1)c1ccccc1
Structure:
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