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Target
Kappa-type opioid receptor
Ligand
BDBM75417
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule agonists of the kappa opioid receptor via a luminescent beta-arrestin assay - Set 3
EC50
14200±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule agonists of the kappa opioid receptor via a luminescent beta-arrestin assay - Set 3 PubChem Bioassay (2010)[AID] 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM75417
Synonyms:
2-[5-[(4-bromobenzyl)thio]-4-(2-chlorobenzyl)-1,2,4-triazol-3-yl]pyridine | 2-[5-[(4-bromophenyl)methylsulfanyl]-4-[(2-chlorophenyl)methyl]-1,2,4-triazol-3-yl]pyridine | 2-[5-[(4-bromophenyl)methylthio]-4-[(2-chlorophenyl)methyl]-1,2,4-triazol-3-yl]pyridine | KSC-12-171-B1 | KUC105579N | cid_45479188
Type:
Small organic molecule
Emp. Form.:
C21H16BrClN4S
Mol. Mass.:
471.801
SMILES:
Clc1ccccc1Cn1c(SCc2ccc(Br)cc2)nnc1-c1ccccn1
Structure:
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