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Target
Kappa-type opioid receptor
Ligand
BDBM75424
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule agonists of the kappa opioid receptor via a luminescent beta-arrestin assay - Set 3
EC50
2220±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule agonists of the kappa opioid receptor via a luminescent beta-arrestin assay - Set 3 PubChem Bioassay (2010)[AID] 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM75424
Synonyms:
2-[4-benzyl-5-[[4-chloro-3-(trifluoromethyl)benzyl]thio]-1,2,4-triazol-3-yl]pyridine | 2-[4-benzyl-5-[[4-chloro-3-(trifluoromethyl)phenyl]methylsulfanyl]-1,2,4-triazol-3-yl]pyridine | 2-[5-[[4-chloranyl-3-(trifluoromethyl)phenyl]methylsulfanyl]-4-(phenylmethyl)-1,2,4-triazol-3-yl]pyridine | 2-[5-[[4-chloro-3-(trifluoromethyl)phenyl]methylthio]-4-(phenylmethyl)-1,2,4-triazol-3-yl]pyridine | KSC-12-171-C3 | KUC105586N | cid_45479182
Type:
Small organic molecule
Emp. Form.:
C22H16ClF3N4S
Mol. Mass.:
460.902
SMILES:
FC(F)(F)c1cc(CSc2nnc(-c3ccccn3)n2Cc2ccccc2)ccc1Cl
Structure:
Search PDB for entries with ligand similarity: